INT235947

Context Info Confidence 0.37 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.25 Pain Relevance 0.22

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4) cytoplasm (Aqp4)

Anatomy Link Frequency brain 2 Aqp4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 17 94.08 Central nervous system 61 93.56 Spinal cord 28 81.12 Neuritis 25 5.00 Multiple sclerosis 16 5.00 cytokine 5 5.00 medulla 3 5.00 tolerance 3 5.00 intrathecal 2 5.00 Demyelination 2 5.00

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 2 99.96 Infection 19 98.48 Stroke 1 96.80 Creutzfeldt Jakob Disease 1 95.96 Disease 52 94.60 INFLAMMATION 18 94.08 Neuromyelitis Optica 215 78.60 Autoimmune Disease 22 71.96 Immunization 6 54.24 Multiple Sclerosis 31 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Perhaps the importance of AQP4 for regulating brain edema suggests that when its function is interrupted and the BBB is compromised, immunopathology ensues.

Regulation (regulating) of Localization (importance) of AQP4 in brain associated with pressure and volume under development

1) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.25 Pain Relevance 0.22

General Comments

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