INT235951

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.13
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
lymphocytes 2
B cells 2
astrocyte 2
optic nerve 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 1 98.76 Very High Very High Very High
Inflammatory mediators 2 98.44 Very High Very High Very High
Central nervous system 123 97.44 Very High Very High Very High
cytokine 10 91.68 High High
cva 12 91.08 High High
Spinal cord 56 79.28 Quite High
Multiple sclerosis 32 78.00 Quite High
imagery 28 42.40 Quite Low
Neuritis 51 40.16 Quite Low
ischemia 5 35.20 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 45 99.82 Very High Very High Very High
Ocular Hypertension 75 99.46 Very High Very High Very High
Neuromyelitis Optica 434 99.22 Very High Very High Very High
Infection 38 99.22 Very High Very High Very High
INFLAMMATION 36 98.24 Very High Very High Very High
Disease 109 94.48 High High
Intracranial Hypertension 7 91.08 High High
Glaucoma 18 88.76 High High
Hypertrophy 8 88.32 High High
Injury 16 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems reasonable to hypothesize that AQP4 specific T cells are present in patients with NMO-IgG as AQP4 is a protein antigen that requires T cell help for induction of AQP4-specific B cells.
Positive_regulation (requires) of Positive_regulation (induction) of AQP4 in B cells associated with neuromyelitis optica
1) Confidence 0.57 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.09 Pain Relevance 0.19
At two weeks, increased abundance of AQP4 expressed in astrocyte processes of the periventricular region was found, together with significant elevated ADC values.
Positive_regulation (increased) of Positive_regulation (abundance) of AQP4 in astrocyte
2) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.81 Pain Relevance 0.25
These observations suggest that IOP elevation is an important factor for increasing the levels of AQP4 and GFAP, which could promote glial activation at the optic nerve.
Positive_regulation (factor) of Positive_regulation (increasing) of AQP4 in optic nerve associated with ocular hypertension and glial activation
3) Confidence 0.49 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.24 Pain Relevance 0.05
Changes in AQP4 expression in CNS and non-CNS tissue can be regulated by inflammatory mediators induced during and following infection or by underlying autoimmunity and can result in the induction of AQP4-specific lymphocytes and ensuing pathogenesis.
Positive_regulation (result) of Positive_regulation (induction) of AQP4 in lymphocytes associated with inflammatory mediators, autoimmune disease, central nervous system and infection
4) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.00 Pain Relevance 0.26

General Comments

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