INT235953

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.40
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
ependymal cells 2
B cell 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 184 95.40 Very High Very High Very High
imagery 30 77.68 Quite High
Neuritis 75 66.04 Quite High
Spinal cord 84 56.96 Quite High
Inflammation 51 56.96 Quite High
tolerance 9 35.20 Quite Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
cva 12 5.00 Very Low Very Low Very Low
medulla 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 645 100.00 Very High Very High Very High
Infection 57 96.24 Very High Very High Very High
Genetic Predisposition To Disease 3 95.36 Very High Very High Very High
Hydrocephalus 43 92.28 High High
Disease 158 71.24 Quite High
Transverse Myelitis 42 68.24 Quite High
Optic Neuritis 72 66.04 Quite High
INFLAMMATION 54 56.96 Quite High
Autoimmune Disease 66 33.12 Quite Low
Multiple Sclerosis 93 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactivity of AQP4 both in controls and hydrocephalic rats localised to the basolateral membrane of the ependymal cells lining the ventricular wall, thus confirming conserved polarisation of the AQP4 positive ependymal cells in hydrocephalus.


Regulation (controls) of AQP4 Binding (Immunoreactivity) of in ependymal cells associated with hydrocephalus
1) Confidence 0.45 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.16 Pain Relevance 0.04
2) Do the different AQP4-expressing tissues and perhaps the membrane structural organization of AQP4 influence NMO-IgG binding efficacy and thus pathogenesis?
Regulation (organization) of AQP4 Binding (binding) of associated with neuromyelitis optica
2) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.97 Pain Relevance 0.34
2) Do the different AQP4-expressing tissues and perhaps the membrane structural organization of AQP4 influence NMO-IgG binding efficacy and thus pathogenesis?
Regulation (influence) of AQP4 Binding (binding) of associated with neuromyelitis optica
3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.96 Pain Relevance 0.34
Thus the binding of human NMO-IgG to murine AQP4 suggests at least three interpretations: 1) that Loop A is not a B cell epitope, 2) the changes between rodents and humans do not affect antibody binding if the loop A sequence is a B cell epitope., or 3) the sequence changes do affect binding of anti-AQP4 antibodies, but other AQP4 epitopes are still available and antibodies in polyclonal sera have enough reactivity to AQP4 to be scored as positive for binding if one AQP4 epitope is compromised.
Regulation (affect) of AQP4 Binding (binding) of in B cell associated with neuromyelitis optica
4) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.30 Pain Relevance 0.04

General Comments

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