INT235954

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.77
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcr) plasma membrane (Bcr) enzyme binding (Bcr)
cytoplasm (Bcr)
Anatomy Link Frequency
B cell 2
Mouse 1
lymphocytes 1
spinal cord 1
APC 1
Bcr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 102 98.20 Very High Very High Very High
Spinal cord 168 97.40 Very High Very High Very High
Neuritis 150 94.88 High High
Multiple sclerosis 96 92.84 High High
Central nervous system 366 87.20 High High
tolerance 18 67.92 Quite High
cytokine 30 17.08 Low Low
medulla 18 5.00 Very Low Very Low Very Low
intrathecal 12 5.00 Very Low Very Low Very Low
Demyelination 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 108 100.00 Very High Very High Very High
Neuromyelitis Optica 1290 98.80 Very High Very High Very High
INFLAMMATION 108 98.20 Very High Very High Very High
Autoimmune Disease 132 97.24 Very High Very High Very High
Optic Neuritis 144 94.88 High High
Disease 312 93.52 High High
Multiple Sclerosis 186 92.84 High High
Sprains And Strains 6 91.52 High High
Infection 114 81.84 Quite High
Viral Infection 30 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-expression of MOG-specific BCR and MOG-TCR transgenic lymphocytes results in isotype switching of the MOG antibodies to IgG1, which in mouse is related to a different Th-profile than that associated with the human AQP4 IgG1 subclass.
Gene_expression (expression) of BCR in lymphocytes associated with targeted disruption
1) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.97 Pain Relevance 0.19
Mice that express both a BCR and a TCR specific for MOG epitopes develop inflammation of the spinal cord.
Gene_expression (express) of BCR in spinal cord associated with inflammation and spinal cord
2) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.12 Pain Relevance 0.29
The human B cell repertoire (germline) has B cell clones that express a BCR reactive to AQP4 either as a bona fide antigen or as a cross reactive species.
Gene_expression (express) of BCR in B cell
3) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.96 Pain Relevance 0.20
Mouse model – MOG-specific BCR transgenic
Gene_expression (transgenic) of BCR in Mouse associated with targeted disruption
4) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.57 Pain Relevance 0.36
Immune responses are dependent on lymphocytes that express antigen-specific or antigen-crossreactive TCR and BCR interacting with the APC they encounter while trafficking in the secondary lymphoid tissue.
Gene_expression (express) of BCR in APC
5) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.15 Pain Relevance 0.24
The human B cell repertoire (germline) has B cell clones that express a BCR reactive to AQP4 either as a bona fide antigen or as a cross reactive species.
Gene_expression (reactive) of BCR in B cell
6) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.01 Pain Relevance 0.20

General Comments

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