INT235956

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.53
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
optic 1
Aqp4 (Rattus norvegicus)
NMO-IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 183 100.00 Very High Very High Very High
Spinal cord 84 99.04 Very High Very High Very High
Neuritis 75 93.84 High High
Multiple sclerosis 48 59.52 Quite High
Inflammation 51 25.00 Low Low
tolerance 9 25.00 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
medulla 9 5.00 Very Low Very Low Very Low
intrathecal 6 5.00 Very Low Very Low Very Low
Demyelination 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 645 100.00 Very High Very High Very High
Disease 156 95.68 Very High Very High Very High
Optic Neuritis 72 94.08 High High
Transverse Myelitis 42 92.16 High High
Targeted Disruption 54 88.32 High High
Multiple Sclerosis 93 83.28 Quite High
Diabetic Nephropathy 3 83.00 Quite High
Myasthenia Gravis 12 78.68 Quite High
Immunization 18 76.64 Quite High
Respiratory Distress 3 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An IgG1 autoantibody (NMO-IgG) that binds aquaporin 4 (AQP4) has been identified in the sera of a significant number of NMO patients, as well as in patients with two related neurologic conditions, bilateral optic neuritis (ON), and longitudinal extensive transverse myelitis (LETM), that are generally considered to lie within the NMO spectrum of diseases.
AQP4 Binding (binds) of NMO-IgG in optic associated with neuromyelitis optica, transverse myelitis, optic neuritis, disease and neuritis
1) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.31 Pain Relevance 0.30
The similarity of the AQP4 protein sequence between humans and these rodents, and the fact that human NMO-IgG binds murine CNS AQP4 further substantiates the feasibility of developing an AQP4-based rodent model of NMO.
AQP4 Binding (binds) of NMO-IgG associated with neuromyelitis optica and central nervous system
2) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.44 Pain Relevance 0.20
NMO-IgG has been shown to bind to AQP4 and confirmed by several labs.
AQP4 Binding (bind) of NMO-IgG associated with neuromyelitis optica
3) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.77 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox