INT235958

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.32
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
optic 1
Ighg1 (Mus musculus)
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 28 99.80 Very High Very High Very High
Neuritis 25 93.84 High High
Central nervous system 61 68.16 Quite High
Inflammation 17 25.00 Low Low
tolerance 3 25.00 Low Low
Multiple sclerosis 16 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 215 100.00 Very High Very High Very High
Disease 52 96.44 Very High Very High Very High
Optic Neuritis 24 94.08 High High
Transverse Myelitis 14 92.16 High High
Autoimmune Disease 22 25.00 Low Low
Infection 19 25.00 Low Low
INFLAMMATION 18 25.00 Low Low
Genetic Predisposition To Disease 1 25.00 Low Low
Multiple Sclerosis 31 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An IgG1 autoantibody (NMO-IgG) that binds aquaporin 4 (AQP4) has been identified in the sera of a significant number of NMO patients, as well as in patients with two related neurologic conditions, bilateral optic neuritis (ON), and longitudinal extensive transverse myelitis (LETM), that are generally considered to lie within the NMO spectrum of diseases.
IgG1 Binding (binds) of AQP4 in optic associated with neuromyelitis optica, transverse myelitis, optic neuritis, disease and neuritis
1) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.32 Pain Relevance 0.30

General Comments

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