INT235961

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.90 Pain Relevance 0.14

cytoplasm (Nqo1, Aqp4) cytosol (Nqo1) oxidoreductase activity (Nqo1) plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)

Nqo1 (Mus musculus) Aqp4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Central nervous system 61 94.12 Multiple sclerosis 16 72.96 Spinal cord 28 63.76 Neuritis 25 5.00 Inflammation 17 5.00 cytokine 5 5.00 medulla 3 5.00 tolerance 3 5.00 intrathecal 2 5.00 Demyelination 2 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 215 100.00 Autoimmune Disease 22 93.96 Multiple Sclerosis 31 82.80 Disease 52 55.68 Infection 19 52.48 Herpes Zoster 2 39.28 Cytomegalovirus Infection 2 28.04 Herpes Virus Infection 1 23.68 Dengue 2 20.80 Demyelinating Disease 7 20.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus the target sequences within AQP4 with which to investigate NMO are beginning to be realized and thus soon will be available to develop AQP4 animal model based on those enumerated and developed for MOG-induced CNS autoimmunity.

NMO Binding (investigate) of AQP4 associated with neuromyelitis optica, autoimmune disease and central nervous system

1) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.90 Pain Relevance 0.14

General Comments

This test has worked.