INT235975

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.11
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
brain 2
optic 1
AQP4 (Homo sapiens)
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 58 99.04 Very High Very High Very High
Neuritis 34 93.60 High High
Demyelination 14 79.36 Quite High
Central nervous system 61 67.68 Quite High
addiction 9 55.04 Quite High
cytokine 11 45.28 Quite Low
Multiple sclerosis 34 43.72 Quite Low
ischemia 6 30.64 Quite Low
Inflammation 32 25.00 Low Low
tolerance 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 386 100.00 Very High Very High Very High
Targeted Disruption 51 99.96 Very High Very High Very High
Disease 259 95.68 Very High Very High Very High
Optic Neuritis 33 93.84 High High
Necrosis 8 92.32 High High
Transverse Myelitis 14 91.92 High High
Demyelinating Disease 49 79.36 Quite High
Hyalinosis 3 63.32 Quite High
Hyperplasia 3 62.56 Quite High
Edema 9 38.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, using sera from NMO-IgG positive patients on brain tissue obtained from AQP4 knock-out mice, Lennon and colleagues [53] showed that neither human serum IgG from NMO patients nor rabbit anti-AQP4 IgG bound detectably to the AQP4 knock-out mouse brain tissues (Fig. (1)).
AQP4 Binding (bound) of IgG in brain associated with targeted disruption and neuromyelitis optica
1) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.85 Pain Relevance 0.03
Moreover, using sera from NMO-IgG positive patients on brain tissue obtained from AQP4 knock-out mice, Lennon and colleagues [53] showed that neither human serum IgG from NMO patients nor rabbit anti-AQP4 IgG bound detectably to the AQP4 knock-out mouse brain tissues (Fig. (1)).
AQP4 Binding (bound) of IgG in brain associated with targeted disruption and neuromyelitis optica
2) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.86 Pain Relevance 0.03
The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.
AQP4 Binding (interaction) of IgG associated with neuromyelitis optica
3) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.09 Pain Relevance 0.17
An IgG1 autoantibody (NMO-IgG) that binds aquaporin 4 (AQP4) has been identified in the sera of a significant number of NMO patients, as well as in patients with two related neurologic conditions, bilateral optic neuritis (ON), and longitudinal extensive transverse myelitis (LETM), that are generally considered to lie within the NMO spectrum of diseases.
aquaporin 4 Binding (binds) of NMO-IgG in optic associated with neuromyelitis optica, transverse myelitis, optic neuritis, disease and neuritis
4) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.31 Pain Relevance 0.30

General Comments

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