INT23598

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Context Info
Confidence 0.40
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 16.00
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
embryo 5
skeletal muscle 1
brain 1
olfactory nerve 1
band 1
SCN5A (Homo sapiens)
SCN5A - N406S (1) SCN5A - D1790G (1)
Pain Link Frequency Relevance Heat
tetrodotoxin 128 100.00 Very High Very High Very High
sodium channel 37 99.60 Very High Very High Very High
lidocaine 8 99.46 Very High Very High Very High
Endep 13 99.36 Very High Very High Very High
depression 31 99.30 Very High Very High Very High
agonist 48 99.24 Very High Very High Very High
Angina 6 98.62 Very High Very High Very High
endometriosis 19 98.58 Very High Very High Very High
local anesthetic 6 98.28 Very High Very High Very High
anesthesia 5 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fasciitis 24 100.00 Very High Very High Very High
Hypoglycemia 20 100.00 Very High Very High Very High
Renal Insufficiency 2 100.00 Very High Very High Very High
Congenital Anomalies 53 99.98 Very High Very High Very High
Channelopathies 8 99.96 Very High Very High Very High
Heart Arrhythmia 50 99.76 Very High Very High Very High
Cv Unclassified Under Development 10 99.76 Very High Very High Very High
Hypopituitarism 1 99.68 Very High Very High Very High
Syndrome 364 99.44 Very High Very High Very High
Depression 39 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review aims to evaluate whether severe endometriosis has an impact on the outcome of in vitro fertilisation (IVF), whether IVF is associated with specific complications in this context, whether a specific ovarian stimulation protocol is most appropriate, whether the endometrial condition progresses following ovarian stimulation, and whether endometrial cysts pose a specific problem for IVF.
IVF Binding (associated) of associated with endometriosis and cyst
1) Confidence 0.40 Published 2009 Journal Gynecol. Endocrinol. Section Abstract Doc Link 19908950 Disease Relevance 0.53 Pain Relevance 0.18
Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21.
SCN5A Binding (Assignment) of in band associated with tetrodotoxin
2) Confidence 0.37 Published 1995 Journal Cytogenet. Cell Genet. Section Title Doc Link 7956363 Disease Relevance 0 Pain Relevance 0.10
Inactivation of SCN1A and SCN2A [3] genes have been associated with epilepsy, SCN4A is associated with myotonia disorders [4], SCN5A is associated with Brugada syndrome (OMIM 601144) [5], which is characterized by cardiac arrhythmias in young people, and SCN8A is associated with cerebellar atrophy and ataxia [6].
SCN5A Binding (associated) of associated with epilepsy, ataxia, frailty, heart arrhythmia and hypopituitarism
3) Confidence 0.34 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.31 Pain Relevance 1.03
The first conclusion is supported by the observation that conduction abnormalities were often associated with SCN5A channelopathies, like isolated CCD or LQT3 [6].
SCN5A Binding (associated) of associated with cv unclassified under development, disease and channelopathies
4) Confidence 0.31 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857368 Disease Relevance 1.09 Pain Relevance 0.25
Improved consultation is also suggested to facilitate the decision-making process for the couple on when to end IVF (29).
IVF Binding (end) of
5) Confidence 0.30 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.32 Pain Relevance 0.03
Frustrated at the ending of IVF
IVF Binding (ending) of
6) Confidence 0.30 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.16 Pain Relevance 0
Eleven women who completed IVF or cryo-embryo transfer treatments did not achieve an ongoing pregnancy.
IVF Binding (completed) of in embryo
7) Confidence 0.29 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2806181 Disease Relevance 0.23 Pain Relevance 0
Some patients with insurance excluding IVF had to pay for these procedures.
IVF Binding (pay) of
8) Confidence 0.29 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2806181 Disease Relevance 0.09 Pain Relevance 0
These findings nevertheless also add a novel Na+ channel variant to available recent reports that have associated SCN5A mutations with a range of phenotypes extending even to SSS (Bezzina et al. 1999, Veldkamp et al. 2000, Benson et al. 2003, Groenewegen et al. 2003, Makiyama et al. 2005, Remme et al. 2006).
SCN5A Binding (associated) of associated with heart rate under development
9) Confidence 0.29 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0.54 Pain Relevance 0
(Ruth, gave birth to an IVF daughter on the 13th embryo transfer and two years later, an IVF son)
IVF daughter Binding (birth) of in embryo
10) Confidence 0.29 Published 2008 Journal Reprod Health Section Body Doc Link PMC2583986 Disease Relevance 0.10 Pain Relevance 0
Of the patients who underwent IUI treatment first, 45 couples continued with IVF after unsuccessful IUI treatment, 36 patients became pregnant due to IUI, 39 patients stopped treatment before, during or after IUI treatment.
IVF Binding (continued) of
11) Confidence 0.28 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2632644 Disease Relevance 0 Pain Relevance 0
Opponents of stem cell research, echoing earlier opposition to IVF and PGD, focus on when life is morally significant, and how death is defined, speaking of embryos being ‘killed’, in language rigorously avoided by proponents on the other side of the debate (2003: 803).
IVF Binding (opposition) of in stem cell associated with death
12) Confidence 0.28 Published 2008 Journal Sociology of Health & Illness Section Body Doc Link PMC2592482 Disease Relevance 0.10 Pain Relevance 0
Their occurrence in LQT3 patients represents an important warning signal, which requires reinforcing safety measures.


LQT3 Binding (occurrence) of
13) Confidence 0.28 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.80 Pain Relevance 0
This has led both LQT2 (also at risk while resting) and LQT3 patients to be saved by a family member, such as the spouse sleeping in the same bed.
LQT3 Binding (saved) of
14) Confidence 0.28 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.41 Pain Relevance 0.13
If a child experiences permanent morbidity the consequences are lifelong, and thus data on long-term costs and outcomes associated with singletons and twins born after IVF should be included in the analysis in order to obtain a valid estimate of the incremental cost-effectiveness of different embryo transfer strategies.
IVF Binding (associated) of in embryo
15) Confidence 0.26 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0 Pain Relevance 0
Indeed, QT interval duration, genotype and gender are significantly associated with the outcome with a QTc interval >500ms, and a LQT2 or LQT3 genotype determining the worst prognosis.
LQT3 Spec (determining) Binding (associated) of
16) Confidence 0.26 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.98 Pain Relevance 0
Mutations in the SCN5A gene may also modify the interaction with the sodium channel beta-subunit and with other proteins controlling intracellular localization of the channel.
SCN5A Binding (interaction) of associated with sodium channel
17) Confidence 0.26 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.77 Pain Relevance 0.17
A substitution at either hH1-F1760K or hH1-Y1767K significantly increases the IC(50) values for resting and inactivated states of amitriptyline, but the increase is much more pronounced with the hH1-F1760K mutation.
hH1 (F1760K) Binding (pronounced) of associated with endep
18) Confidence 0.23 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10688618 Disease Relevance 0.21 Pain Relevance 0.78
Hence, the current available evidence suggests the increased risk of congenital malformation associated with IVF is not attributable to ICSI, per se, and may be related to other factors such as patient characteristics, ovarian stimulation protocols, or embryo culture environment.
IVF Binding (associated) of in embryo associated with congenital anomalies
19) Confidence 0.21 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936357 Disease Relevance 0.47 Pain Relevance 0
The authors investigated the interaction of bupivacaine enantiomers with hH1 Na+ channels, assessed the contribution of putatively relevant residues to binding, and compared the intrinsic affinities to another isoform, the rat skeletal muscle (mu1) Na+ channel.
hH1 Binding (interaction) of in skeletal muscle
20) Confidence 0.19 Published 2000 Journal Anesthesiology Section Abstract Doc Link 11020758 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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