INT235983

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 6.47
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sag)
Anatomy Link Frequency
photoreceptor cell 1
glutamatergic neurons 1
T cells 1
Sag (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 96.52 Very High Very High Very High
5HT 45 89.52 High High
Serotonin 30 5.00 Very Low Very Low Very Low
fluoxetine 24 5.00 Very Low Very Low Very Low
Pyramidal cell 20 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 665 99.08 Very High Very High Very High
Disease 22 99.08 Very High Very High Very High
Cancer 65 98.00 Very High Very High Very High
Apoptosis 388 97.36 Very High Very High Very High
Thymoma 7 95.60 Very High Very High Very High
Sprains And Strains 25 93.36 High High
Infection 35 86.52 High High
Death 43 84.92 Quite High
Targeted Disruption 3 81.24 Quite High
Adenocarcinoma 7 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-Arrestin is highly expressed in postsynaptic synapses of glutamatergic neurons (33), where both 5-HT receptors and NMDA receptors are abundant.
Gene_expression (expressed) of Arrestin in glutamatergic neurons associated with nmda receptor
1) Confidence 0.58 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0.08 Pain Relevance 0.16
Although the majority of these endogenous proviral sequences do not produce viral particles because of mutations in their regulatory or coding regions, all of them express a Sag which is encoded in their LTR region [12]–[13].
Gene_expression (express) of Sag
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.62 Pain Relevance 0
Interestingly, our results show that a lymphoma that escaped thymic negative selection driven by an endogenous viral Sag (Mtv-9), and thus expresses a forbidden V?
Gene_expression (endogenous) of Sag associated with lymphatic system cancer
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.31 Pain Relevance 0
Whereas Sag exposure did not induce alterations in the expression of Bcl-2, TRAIL or TNFR1, interaction of Sags with the cognate V?
Gene_expression (exposure) of Sag
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.08 Pain Relevance 0
Interestingly, our results show that a lymphoma that escaped thymic negative selection driven by an endogenous viral Sag (Mtv-9), and thus expresses a forbidden V?
Gene_expression (viral) of Sag associated with lymphatic system cancer
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.30 Pain Relevance 0
Moreover, the permanent expression of a retroviral-encoded Sag was able to induce the complete remission of the neoplasia in a high percentage of mice.


Gene_expression (expression) of Sag associated with cancer
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.70 Pain Relevance 0
T14 cells showed a significant increase in their proliferative levels when co-cultured with splenocytes expressing the Sag encoded by MMTV BALB14 [17] whereas no alterations were detected when these cells were co-cultured with splenocytes infected with MMTV BALB2 which encodes for a Sag specific for V?
Gene_expression (expressing) of Sag
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.57 Pain Relevance 0
The effect of an MMTV-encoded Sag on the survival of cognate lymphoma T cells was also investigated.
Spec (investigated) Gene_expression (effect) of Sag in T cells associated with lymphatic system cancer
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.54 Pain Relevance 0
However, expressions of other photoreceptor cell specific proteins including Rho, transducin, arrestin and recoverin were almost comparable between RCS and control rats (Maeda et al 2002).
Gene_expression (expressions) of arrestin in photoreceptor cell
9) Confidence 0.01 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.28 Pain Relevance 0

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