INT236014

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
Cleavage 1
HIST2H2AA3 (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 2 38.96 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 34 95.60 Very High Very High Very High
Amyloid Plaque 70 95.12 Very High Very High Very High
Alzheimer's Dementia 72 50.40 Quite High
Death 10 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Hypopigmentation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-Secretase-mediated APP Cleavage through JNK Activation—It has been shown that H2O2 activates JNK, one of the mitogen-activated protein kinases that is readily activated in response to various environmental stresses, to decide the fate of cells (32).
H2O2 Positive_regulation (activates) of JNK in Cleavage associated with stress
1) Confidence 0.02 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.27 Pain Relevance 0
We found that in addition to JNK, ERK and PKB were activated by H2O2 (Fig. 6, A and B).
H2O2 Positive_regulation (activated) of JNK
2) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.17 Pain Relevance 0

General Comments

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