INT23606

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Context Info
Confidence 0.25
First Reported 1980
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 3.33
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atp2b4)
Anatomy Link Frequency
brain 4
liver 1
putamen 1
cerebral cortex 1
lens 1
Atp2b4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 10 100.00 Very High Very High Very High
aspirin 4 100.00 Very High Very High Very High
isoflurane 14 99.46 Very High Very High Very High
cerebral cortex 2 98.20 Very High Very High Very High
antiarrhythmic agent 1 89.64 High High
halothane 6 88.76 High High
Bile 6 61.84 Quite High
Pain 3 61.36 Quite High
addiction 4 48.56 Quite Low
anesthesia 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Aging 9 100.00 Very High Very High Very High
Diabetes Mellitus 22 98.54 Very High Very High Very High
Stress 57 97.26 Very High Very High Very High
Injury 14 96.68 Very High Very High Very High
Neuropathic Pain 2 95.68 Very High Very High Very High
Sprains And Strains 10 88.00 High High
Disorder Of Lipid Metabolism 6 86.24 High High
Hepatotoxicity 53 75.00 Quite High
Poisoning 1 73.60 Quite High
Pain 1 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strong association between age and reduced anesthetic requirements for inhalational agents on the one hand and altered PMCA and PLMTI activity on the other lends support to the underlying hypothesis that PMCA and PLMTI may be involved in the production of the anesthetic state.
Regulation (altered) of PMCA
1) Confidence 0.25 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890927 Disease Relevance 0.20 Pain Relevance 0.27
In addition, we examined the effect of insulin treatment, begun 2 weeks after induction of diabetes and continued for 3 more weeks, on isoflurane MED and on brain synaptic PMCA and phospholipid-N-methyltransferase I (PLMT I), another enzyme altered by inhalation anesthetics (IA).
Regulation (altered) of PMCA in brain associated with diabetes mellitus and isoflurane
2) Confidence 0.17 Published 1995 Journal Life Sci. Section Abstract Doc Link 7752806 Disease Relevance 0.77 Pain Relevance 0.24
In addition, we examined the effect of insulin treatment, begun 2 weeks after induction of diabetes and continued for 3 more weeks, on isoflurane MED and on brain synaptic PMCA and phospholipid-N-methyltransferase I (PLMT I), another enzyme altered by inhalation anesthetics (IA).
Regulation (altered) of PMCA in brain associated with diabetes mellitus and isoflurane
3) Confidence 0.13 Published 1995 Journal Life Sci. Section Abstract Doc Link 7752806 Disease Relevance 0.77 Pain Relevance 0.24
The present studies were carried out to study the effect of amiodarone on rat brain synaptosomal ATPases in an effort to understand its mechanism of action.
Regulation (effect) of ATPases in brain
4) Confidence 0.10 Published 1986 Journal Cell Biochem. Funct. Section Abstract Doc Link 2423267 Disease Relevance 0.10 Pain Relevance 0.04
Hepatic injury elicits intracellular stress that leads to peroxidation of membrane lipids accompanied by alteration of structural and functional characteristics of membrane, which affect the activities of membrane-bound ATPases.
Regulation (affect) of ATPases associated with stress and injury
5) Confidence 0.07 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15234779 Disease Relevance 0.43 Pain Relevance 0.23
Figure 2 indicates the effect of CsA and sulphated polysaccharides on ATPases activity.
Regulation (effect) of ATPases
6) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.07 Pain Relevance 0
Enhanced damages on the membrane are further evident from altered ATPases activities in the liver tissue of CsA administered groups.
Spec (evident) Regulation (altered) of ATPases in liver
7) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.22 Pain Relevance 0.03
The influence of aging and pre- and post-mortem conditions on the activities of glycolytic enzymes and of the ATPases was determined in samples of autoptic human cerebral cortex and putamen.
Regulation (influence) of ATPases in putamen associated with aging and cerebral cortex
8) Confidence 0.01 Published 1980 Journal Aktuelle Gerontol Section Abstract Doc Link 6106427 Disease Relevance 0.26 Pain Relevance 0.05
Ca2+ ATPases are also reported to be sensitive to membrane lipid order and their decreased activity may be related to structural changes in membrane lipids [38].
Regulation (sensitive) of ATPases
9) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.07 Pain Relevance 0
Earlier reports have shown that Ca2+ ATPases are particularly sensitive to oxidation and that oxidative damage leads to decreased activity of these enzymes, resulting in elevated levels of Ca2+ in the lens [37].
Regulation (sensitive) of ATPases in lens
10) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.17 Pain Relevance 0
The influence of aging and pre- and post-mortem conditions on the activities of glycolytic enzymes and of the ATPases was determined in samples of autoptic human cerebral cortex and putamen.
Regulation (influence) of ATPases in cerebral cortex associated with aging and cerebral cortex
11) Confidence 0.00 Published 1980 Journal Aktuelle Gerontol Section Abstract Doc Link 6106427 Disease Relevance 0.26 Pain Relevance 0.05
Effects of aspirin and paracetamol on ATPases of human fetal brain: an in vitro study.
Regulation (Effects) of ATPases in brain associated with aspirin and paracetamol
12) Confidence 0.00 Published 1989 Journal Indian J. Exp. Biol. Section Title Doc Link 2561117 Disease Relevance 0 Pain Relevance 0.48

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