INT23609

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Context Info
Confidence 0.33
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.69
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
neurons 1
nerve 1
spinal cord 1
osteoclast 1
hypertrophic chondrocytes 1
Acp5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 5 100.00 Very High Very High Very High
qutenza 3 99.84 Very High Very High Very High
Dorsal horn 7 98.40 Very High Very High Very High
Spinal cord 6 97.64 Very High Very High Very High
Sciatic nerve 5 90.96 High High
Osteoarthritis 2 82.88 Quite High
Snapping jaw 3 82.28 Quite High
Somatostatin 4 81.60 Quite High
Cholecystokinin 4 80.00 Quite High
Pain 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Frailty 2 98.36 Very High Very High Very High
Nociception 3 95.84 Very High Very High Very High
Hypoxia 4 91.44 High High
Repression 1 88.04 High High
Osteoarthritis 2 82.88 Quite High
Temporomandibular Joint Syndrome 3 82.28 Quite High
Pain 3 75.00 Quite High
Intractable Pain 1 66.96 Quite High
Bone Cancer 2 61.48 Quite High
Headache 1 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcutaneous iontophoresis of microtubule inhibitors (Vinblastin, Vincristin, Formyl-Leurosin) in rats induces depletion of fluoride-resistant acid phosphatase (FRAP) and transganglionic degenerative atrophy (trggl. deg. atr.) of the central terminals of primary nociceptive neurons, probably via blockade of axoplasmic transport in the peripheral sensory nerves.
Spec (probably) Negative_regulation (depletion) of fluoride-resistant acid phosphatase in neurons associated with nociception and frailty
1) Confidence 0.33 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 6183918 Disease Relevance 0.73 Pain Relevance 0.28
Hif-1alpha expression was observed specifically in mature and hypertrophic chondrocytes, and Hif-1alpha-positivity, level of Vegf expression, and tartrate-resistant acid phosphatase (TRAP)-positive cell numbers all increased in the same manner.
Negative_regulation (numbers) of tartrate-resistant acid phosphatase in hypertrophic chondrocytes
2) Confidence 0.25 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.72 Pain Relevance 0.31
This pI 5.4 acid phosphatase is partly membrane-bound and is selectively depleted by capsaicin administration.
Negative_regulation (depleted) of pI 5.4 acid phosphatase associated with qutenza
3) Confidence 0.22 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6198462 Disease Relevance 0 Pain Relevance 0.15
Regardless of treatment start time, OPG treatment reduced osteoclast number and tartrate-resistant acid phosphatase levels, increased bone mineral density, preserved normal bone volume and integrity on micro-computed tomography, reduced relative tumor volume in the bone, and reduced staining for glial fibrillary acidic protein in the spinal cord.
Negative_regulation (reduced) of tartrate-resistant acid phosphatase in osteoclast
4) Confidence 0.20 Published 2006 Journal Clin. Exp. Metastasis Section Body Doc Link 16912914 Disease Relevance 0.24 Pain Relevance 0
Peripheral nerve section results in depletion of fluoride-resistant acid phosphatase (FRAP) from the nerve terminals in the dorsal horn of the spinal cord (Schoenen et al., '68) and this has been used in the past to map the termination field of individual nerves (Rustioni et al., '71; Devor and Claman, '80).
Negative_regulation (depletion) of fluoride-resistant acid phosphatase in nerve associated with dorsal horn and spinal cord
5) Confidence 0.12 Published 1985 Journal J. Comp. Neurol. Section Abstract Doc Link 3880359 Disease Relevance 0 Pain Relevance 0.17
Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord.
Negative_regulation (depletion) of fluoride-resistant acid phosphatase in spinal cord associated with qutenza, spinal cord and substance p
6) Confidence 0.09 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 2423358 Disease Relevance 0 Pain Relevance 0.74

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