INT23610

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
neurons 1
spinal cord 1
dorsal root ganglia 1
Acp5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
Neuropeptide 4 99.76 Very High Very High Very High
qutenza 3 99.74 Very High Very High Very High
Spinal cord 4 97.40 Very High Very High Very High
anesthesia 1 96.92 Very High Very High Very High
Somatostatin 4 81.60 Quite High
Cholecystokinin 4 80.00 Quite High
Pain 2 75.00 Quite High
Dorsal horn 2 75.00 Quite High
Sciatic nerve 1 71.04 Quite High
Disease Link Frequency Relevance Heat
Frailty 2 98.36 Very High Very High Very High
Nociception 3 95.84 Very High Very High Very High
Hypercalcemia 4 87.36 High High
Pain 2 75.00 Quite High
Intractable Pain 1 66.96 Quite High
Headache 1 60.64 Quite High
Diabetic Neuropathy 1 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcutaneous iontophoresis of microtubule inhibitors (Vinblastin, Vincristin, Formyl-Leurosin) in rats induces depletion of fluoride-resistant acid phosphatase (FRAP) and transganglionic degenerative atrophy (trggl. deg. atr.) of the central terminals of primary nociceptive neurons, probably via blockade of axoplasmic transport in the peripheral sensory nerves.
Gene_expression (depletion) of fluoride-resistant acid phosphatase in neurons associated with nociception and frailty
1) Confidence 0.51 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 6183918 Disease Relevance 0.73 Pain Relevance 0.28
Histomorphometry was performed after staining of the tartrate-resistant acid phosphatase (TRAP).
Gene_expression (staining) of tartrate-resistant acid phosphatase
2) Confidence 0.47 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8460686 Disease Relevance 0.23 Pain Relevance 0.10
Subpopulations of sensory neurons of rat dorsal root ganglia (DRG) can be identified by the immunocytochemical detection of lactoseries and globoseries carbohydrate differentiation antigens with monoclonal antibodies (MAbs) and by the histochemical demonstration of carbonic anhydrase (CA)- or fluoride-resistant acid phosphatase (FRAP) activities; therefore, these markers, and their coincident expression with neuropeptides, were studied in neurons of the rat small intestine.
Gene_expression (expression) of fluoride-resistant acid phosphatase in dorsal root ganglia associated with neuropeptide
3) Confidence 0.13 Published 1988 Journal J. Comp. Neurol. Section Abstract Doc Link 3143749 Disease Relevance 0 Pain Relevance 0.11
Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord.
Gene_expression (produces) of fluoride-resistant acid phosphatase in spinal cord associated with qutenza, spinal cord and substance p
4) Confidence 0.12 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 2423358 Disease Relevance 0 Pain Relevance 0.74

General Comments

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