INT236107

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) signal transduction (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1)
plasma membrane (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
plasma 1
Pdpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 87.12 High High
agonist 22 77.52 Quite High
cINOD 2 69.52 Quite High
antagonist 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 29 97.92 Very High Very High Very High
Tuberous Sclerosis 1 87.60 High High
INFLAMMATION 6 87.12 High High
Colitis 1 77.92 Quite High
Starvation 6 77.20 Quite High
Colon Cancer 10 73.76 Quite High
Apoptosis 7 73.12 Quite High
Targeted Disruption 9 35.80 Quite Low
Polyps 4 28.40 Quite Low
Intestinal Polyps 1 18.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GW501516 exhibit an association between PDK1 and PPAR?
PDK1 Binding (association) of
1) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 1.21 Pain Relevance 0.39
Activated PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the plasma membrane, which increases the membrane recruitment of Akt/PKB and its activator PDK1, leading to the activation of Akt.
PDK1 Binding (recruitment) of in plasma
2) Confidence 0.11 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0

General Comments

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