INT236108

Context Info Confidence 0.39 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.30 Pain Relevance 0.04

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency stem cell 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat agonist 22 89.56 imagery 10 5.00 Inflammation 6 5.00 cINOD 2 5.00 Pain 2 5.00 antagonist 2 5.00 palliative 1 5.00 anesthesia 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Cancer 233 99.70 Apoptosis 7 98.60 Endometrial Cancer 67 82.72 Skin Cancer 6 82.68 Disease 5 74.80 Adhesions 2 70.00 Thyroid Neoplasm 2 68.60 Pancreatic Cancer 1 63.64 Leukemia 1 62.68 Lung Cancer 6 62.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, the upregulation of proapoptotic mechanisms involving AKT-dependent mechanisms is mediated through PTEN, as is the downregulation of anti-apoptotic mechanisms through Bcl-2 [29–31].

Positive_regulation (mediated) of Positive_regulation (upregulation) of PTEN associated with apoptosis

1) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 0.91 Pain Relevance 0

Since inactivation of BRCA1 [25] and PTEN [26–28] also increases stem cell

Positive_regulation (increases) of Positive_regulation (inactivation) of PTEN in stem cell

2) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.53 Pain Relevance 0.04

Mechanisms of resistance in specific tumors could involve activation of insulin-like growth factor (IGF)-1 signaling, activation of Met signaling, loss of PTEN, or mutation of K-Ras that can compensate for the therapeutic inhibition of EGFR signaling.

Positive_regulation (activation) of Positive_regulation (activation) of PTEN associated with cancer

3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716529 Disease Relevance 0.86 Pain Relevance 0

General Comments

This test has worked.