INT236138

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.83
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
Anatomy Link Frequency
myocytes 2
skeletal muscle cell 2
adipocytes 1
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 154 99.62 Very High Very High Very High
agonist 156 88.96 High High
aspirin 1 88.96 High High
Inflammation 39 76.04 Quite High
metalloproteinase 9 74.08 Quite High
tolerance 54 40.88 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Immobilon 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 19 99.44 Very High Very High Very High
Insulin Resistance 373 99.28 Very High Very High Very High
Obesity 239 96.72 Very High Very High Very High
Disease 9 92.96 High High
Targeted Disruption 30 91.64 High High
Diabetes Mellitus 64 89.44 High High
Weight Gain 12 78.08 Quite High
INFLAMMATION 40 76.04 Quite High
Metabolic Disorder 25 69.80 Quite High
Hyperglycemia 11 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, mice lacking PTP1B also exhibit increased insulin sensitivity under both dietary or polygenic insulin resistance (31,32).
Negative_regulation (lacking) of PTP1B associated with hyperinsulinism and insulin resistance
1) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.98 Pain Relevance 0.15
It is worth mentioning that inhibition of PTP1B activity by rosiglitazone and T0901317 was reported in skeletal muscle and brown adipocytes under insulin-resistant conditions (6,49).
Negative_regulation (inhibition) of PTP1B in adipocytes associated with obesity
2) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.46 Pain Relevance 0.30
Modulation of insulin sensitivity by IL-6 in mice: a lack of PTP1B prevents chronic effects of IL-6.
Negative_regulation (lack) of PTP1B
3) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.35 Pain Relevance 0
and protection against insulin resistance by this cytokine in mice and cells lacking PTP1B (6,7).
Negative_regulation (lacking) of PTP1B associated with insulin resistance and cytokine
4) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.83 Pain Relevance 0.12
Accordingly, our final goal was to investigate whether PTP1B deficiency confers protection against insulin resistance by IL-6.
Spec (whether) Negative_regulation (deficiency) of PTP1B associated with insulin resistance
5) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.81 Pain Relevance 0.11
RESEARCH DESIGN AND METHODS—We analyzed the impact of IL-6 on insulin action in murine primary myocytes, skeletal muscle cell lines, and mice (wild type and protein-tyrosine phosphatase 1B [PTP1B] deficient).
Negative_regulation (deficient) of protein-tyrosine phosphatase 1B in skeletal muscle cell
6) Confidence 0.41 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.39 Pain Relevance 0.08
RESEARCH DESIGN AND METHODS—We analyzed the impact of IL-6 on insulin action in murine primary myocytes, skeletal muscle cell lines, and mice (wild type and protein-tyrosine phosphatase 1B [PTP1B] deficient).
Negative_regulation (deficient) of PTP1B in skeletal muscle cell
7) Confidence 0.35 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.39 Pain Relevance 0.08
PTP1B deficiency and its heterozygote
Negative_regulation (deficiency) of PTP1B
8) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.84 Pain Relevance 0.04
RESEARCH DESIGN AND METHODS—We analyzed the impact of IL-6 on insulin action in murine primary myocytes, skeletal muscle cell lines, and mice (wild type and protein-tyrosine phosphatase 1B [PTP1B] deficient).
Negative_regulation (deficient) of protein-tyrosine phosphatase 1B in myocytes
9) Confidence 0.14 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.39 Pain Relevance 0.08
RESEARCH DESIGN AND METHODS—We analyzed the impact of IL-6 on insulin action in murine primary myocytes, skeletal muscle cell lines, and mice (wild type and protein-tyrosine phosphatase 1B [PTP1B] deficient).
Negative_regulation (deficient) of PTP1B in myocytes
10) Confidence 0.12 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.39 Pain Relevance 0.08
Two hundred eighty substances were tested for their inhibition of seven phosphatases (CDC25a, MPTPA, MPTPB, PTP1b, SHP-2, VE-PTP, and VHR) in quadruplicates.
Negative_regulation (inhibition) of PTP1b
11) Confidence 0.06 Published 2008 Journal J Chem Biol Section Body Doc Link PMC2698315 Disease Relevance 0 Pain Relevance 0

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