INT236159

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.93
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Th17 cells 1
astrocytes 1
Mir326 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 632 99.64 Very High Very High Very High
Inflammation 112 84.36 Quite High
Central nervous system 108 62.80 Quite High
cytokine 109 55.20 Quite High
imagery 25 5.00 Very Low Very Low Very Low
Spinal cord 24 5.00 Very Low Very Low Very Low
tolerance 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Demyelination 16 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 700 99.64 Very High Very High Very High
Multiple Sclerosis 80 99.60 Very High Very High Very High
Recurrence 28 99.18 Very High Very High Very High
Disease 272 98.08 Very High Very High Very High
Neuromyelitis Optica 4 95.68 Very High Very High Very High
INFLAMMATION 140 84.36 Quite High
Central Nervous System Disease 108 62.80 Quite High
Autoimmune Disease 184 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 40 5.00 Very Low Very Low Very Low
Repression 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a more recent study did not identify any statistically significant change in whole blood miR-326 expression between MS patients and controls [260], one of the three most upregulated miRNA detected in active MS lesions is miR-326 lending further support to the relevance of this miRNA for MS pathogenesis [261].
Gene_expression (expression) of miR-326 in blood associated with multiple sclerosis
1) Confidence 0.11 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.40 Pain Relevance 0.43
In a group of MS patients in relapse, glucocorticoid treatment downregulates miR-326 expression indicating that this miRNA is under control of disease-modifying drugs and thus may be used in the monitoring of therapy responses [258].
Gene_expression (expression) of miR-326 associated with multiple sclerosis, disease and recurrence
2) Confidence 0.11 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.40 Pain Relevance 0.42
In vivo silencing of miR-326 resulted in fewer Th17 cells and mild EAE, and its overexpression led to more Th17 cells and severe EAE.
Gene_expression (silencing) of miR-326 in Th17 cells associated with multiple sclerosis
3) Confidence 0.09 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.22 Pain Relevance 0.36
MiRNA profiling in isolated cells by laser capture microdissection from active and inactive MS lesions showed that the most prominently upregulated miRNAs in active MS lesions, miR-155, miR-650, miR-34a, and miR-326 were detected in both microdissected astrocytes and infiltrating immune cells [261].
Gene_expression (detected) of miR-326 in astrocytes associated with multiple sclerosis
4) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.92 Pain Relevance 0.44
For all of the other dyes tested except PTIR 327 (Figure 3C), essentially the same patterns were seen:, two-fold differences in dye loading had no significant impact on maximum detection distance (PTIR 326, NV Jade); maximum detection distances increased at ?
Gene_expression (detection) of PTIR 326
5) Confidence 0.05 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0 Pain Relevance 0

General Comments

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