INT23620

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 15.10
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4A) extracellular region (C4A)
Anatomy Link Frequency
22RV1 1
cartilage 1
C4A (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 3 99.98 Very High Very High Very High
imagery 1 96.40 Very High Very High Very High
Pain 11 96.28 Very High Very High Very High
Arthritis 3 96.24 Very High Very High Very High
abdominal pain 4 95.44 Very High Very High Very High
cva 4 94.36 High High
Clonidine 4 90.00 High High
Antihistamine 2 87.28 High High
corticosteroid 4 85.76 High High
Inflammation 8 81.60 Quite High
Disease Link Frequency Relevance Heat
Iron Overload 2 99.88 Very High Very High Very High
Systemic Lupus Erythematosus 129 99.80 Very High Very High Very High
Disease 109 99.44 Very High Very High Very High
Flavivirus Infection 80 99.20 Very High Very High Very High
Proteinuria 2 98.90 Very High Very High Very High
Pressure And Volume Under Development 28 98.80 Very High Very High Very High
Apoptosis 18 98.64 Very High Very High Very High
Syndrome 14 98.16 Very High Very High Very High
Lymphoproliferative Disease 1 97.68 Very High Very High Very High
Spinocerebellar Ataxia Type 2 1 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the rate of postoperative analgesia decreased significantly in group C 2 and C 4 compared to group M.
Negative_regulation (decreased) of C 4 associated with analgesia
1) Confidence 0.57 Published 2009 Journal Biosci Trends Section Abstract Doc Link 20103833 Disease Relevance 0.42 Pain Relevance 0.77
Subtotal C4 deficiency and SLE-like disease.
Negative_regulation (deficiency) of C4 associated with disease and systemic lupus erythematosus
2) Confidence 0.51 Published 1986 Journal Acta Derm. Venereol. Section Title Doc Link 2424221 Disease Relevance 0.30 Pain Relevance 0.14
Decreased serum levels of C4 and C1INH activity indicated a diagnosis of C1INH deficiency.
Negative_regulation (Decreased) of C4
3) Confidence 0.44 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 17548946 Disease Relevance 0.36 Pain Relevance 0.30
The clinical findings in connection with these low C4 values are in congruence with the diagnosis of inherited deficiency of C4.
Negative_regulation (deficiency) of C4
4) Confidence 0.43 Published 1986 Journal Acta Derm. Venereol. Section Abstract Doc Link 2424221 Disease Relevance 0.24 Pain Relevance 0.13
Seven are linked to the HL-A region: six are recessive (idiopathic hemochromatosis, C2, C4A, and C4B deficiencies, congenital and late-onset deficiencies) and one is dominant (spinocerebellar ataxia).
Negative_regulation (deficiencies) of C4A associated with spinocerebellar ataxia type 2 and iron overload
5) Confidence 0.42 Published 1986 Journal Adv. Nephrol. Necker Hosp. Section Abstract Doc Link 3006451 Disease Relevance 0.76 Pain Relevance 0.08
RESULTS: There was excellent visualization of the C-3, C-4, C-5, C-6 and C-7 transverse processes in all cases.
Negative_regulation (visualization) of C-4
6) Confidence 0.41 Published 2010 Journal Surg Radiol Anat Section Body Doc Link 20082079 Disease Relevance 0 Pain Relevance 0
Compared with healthy subjects, patients with SLE clearly have lower copy numbers of C4 and C4A, and SLE susceptibility is significantly increased among subjects with only two copies of total C4 but decreased in those with more than five copies of C4 [68].
Negative_regulation (numbers) of C4A associated with systemic lupus erythematosus
7) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.85 Pain Relevance 0
Variable copy number of the complement component C4 (C4A and C4B) leads to different susceptibilities to SLE [67,68].
Negative_regulation (number) of C4 associated with systemic lupus erythematosus
8) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.88 Pain Relevance 0
Compared with healthy subjects, patients with SLE clearly have lower copy numbers of C4 and C4A, and SLE susceptibility is significantly increased among subjects with only two copies of total C4 but decreased in those with more than five copies of C4 [68].
Negative_regulation (numbers) of C4 associated with systemic lupus erythematosus
9) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.85 Pain Relevance 0
The discovery was made during an exacerbation, but the deficiency of C4 persisted in repeated controls after remission.
Negative_regulation (deficiency) of C4
10) Confidence 0.38 Published 1986 Journal Acta Derm. Venereol. Section Abstract Doc Link 2424221 Disease Relevance 0.24 Pain Relevance 0.14
CONCLUSION: The reduction in C6S, C4S, and KS levels after HA injections reflects that HA could help maintain normal cartilage metabolism.
Negative_regulation (reduction) of C4S in cartilage
11) Confidence 0.35 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
Because initial studies showed a functional deficiency of C1 esterase inhibitor and low C4 levels, he was treated with danazol, an attenuated androgen that has proven to be effective in the treatment of angioedema associated with C1 esterase inhibitor deficiency.
Negative_regulation (deficiency) of C4 associated with pressure and volume under development and hereditary angioedema
12) Confidence 0.32 Published 1982 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 6977562 Disease Relevance 0.98 Pain Relevance 0.06
Because initial studies showed a functional deficiency of C1 esterase inhibitor and low C4 levels, he was treated with danazol, an attenuated androgen that has proven to be effective in the treatment of angioedema associated with C1 esterase inhibitor deficiency.
Negative_regulation (inhibitor) of C4 associated with pressure and volume under development and hereditary angioedema
13) Confidence 0.32 Published 1982 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 6977562 Disease Relevance 0.98 Pain Relevance 0.06
RESULTS: After HA injections, levels of C6S, C4S, and KS decreased significantly.
Negative_regulation (decreased) of C4S
14) Confidence 0.30 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
Complement study during acute and asymptomatic periods revealed normal values of C1 esterase inhibitor, C1q, C3, C4, functional activity of C1 inhibitor and CH50.
Negative_regulation (inhibitor) of C4
15) Confidence 0.29 Published 2005 Journal Allergol Immunopathol (Madr) Section Abstract Doc Link 15777525 Disease Relevance 0.83 Pain Relevance 0.18
The laboratory findings revealed moderate proteinuria, erythrocyturia, normal renal function, normotension, reduction of C3, C4 and C1q complement with elevated C1q antibodies.
Negative_regulation (reduction) of C4 associated with proteinuria
16) Confidence 0.28 Published 2001 Journal Med. Klin. (Munich) Section Abstract Doc Link 11370607 Disease Relevance 1.14 Pain Relevance 0.14
Variable copy number of the complement component C4 (C4A and C4B) leads to different susceptibilities to SLE [67,68].
Negative_regulation (number) of C4A associated with systemic lupus erythematosus
17) Confidence 0.17 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.88 Pain Relevance 0
Pregnancy can be associated with laboratory changes, including increases in ESR and C3, and classical complement activation with decreased C4, which complicate disease assessment[11].
Negative_regulation (decreased) of C4 associated with disease
18) Confidence 0.10 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2860355 Disease Relevance 1.38 Pain Relevance 0
Levels of PGE2 (p < 0.05) and C4S (p < 0.05) in the synovialfluid were significantly decreased.
Negative_regulation (decreased) of C4S
19) Confidence 0.10 Published 2001 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11491492 Disease Relevance 0 Pain Relevance 0
In addition, the levels of C4 and factor B were reduced in the more severe DHF patients (grades III and IV).
Negative_regulation (reduced) of C4 associated with flavivirus infection
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.40 Pain Relevance 0

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