INT23621

Context Info Confidence 0.44 First Reported 1983 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 5.07 Pain Relevance 0.84

extracellular space (C4A) extracellular region (C4A)

Anatomy Link Frequency tear 1 plasma 1 fingers 1 PC-3 1 C4A (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 1 98.08 Pain 4 94.12 Chronic pancreatitis 2 89.00 Antihistamine 2 87.28 metalloproteinase 29 86.32 corticosteroid 4 85.76 headache 5 79.76 Potency 6 71.64 abdominal pain 1 65.44 bradykinin 9 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 87 100.00 Cancer 37 99.30 Arthritis 1 98.08 Wound Healing 17 97.92 Myopia 4 97.84 Disease 20 97.64 Hereditary Angioedema 124 97.32 Metastasis 33 94.24 Hepatitis B Virus Infection 57 94.20 Pathologic Dilatation 4 89.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was no change in plasma of C3a desArg, C4a desArg, and C5a desArg (4 hours: mean C3a: 153.4 +/- 11.5 ng/ml versus 176.2 +/- 16.2 ng/ml for saline solution, p = ns; C4a: 159.6 +/- 32 ng/ml versus 151.4 +/- 21 ng/ml, p = ns; C5a: undetectable).

Neg (no) Regulation (change) of C4a in plasma

1) Confidence 0.44 Published 1987 Journal Surgery Section Abstract Doc Link 3303397 Disease Relevance 0.31 Pain Relevance 0.08

Extremely low C4 values were found in a 65-year-old man with relapsing arthritis and skin lesions of many years duration of the scalp, face, hands and feet together with painful ulcerations of the toes and fingers.

Regulation (values) of C4 in fingers associated with pain and arthritis

2) Confidence 0.24 Published 1986 Journal Acta Derm. Venereol. Section Abstract Doc Link 2424221 Disease Relevance 0.25 Pain Relevance 0.14

By measuring the levels of MMP-9 activity and the concentrations of C4S and C6S in human tear fluid from patients undergoing myopic or myopic astigmatic LASIK, we evaluated whether MMP-9 activity is postoperatively correlated with the C4S and C6S concentrations up to 3 months.

Regulation (concentrations) of C4S in tear associated with myopia

3) Confidence 0.23 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915870 Disease Relevance 0.91 Pain Relevance 0.20

Complement study during acute and asymptomatic periods revealed normal values of C1 esterase inhibitor, C1q, C3, C4, functional activity of C1 inhibitor and CH50.

Regulation (values) of C4

4) Confidence 0.18 Published 2005 Journal Allergol Immunopathol (Madr) Section Abstract Doc Link 15777525 Disease Relevance 0.83 Pain Relevance 0.19

C4-C5 level appears to be affected the most frequently, followed by the C3-C4 level, then C2-C3, C5-C6, and C6-C7.

Regulation (affected) of C3-C4

5) Confidence 0.11 Published 2009 Journal Spine J Section Body Doc Link 19477691 Disease Relevance 0 Pain Relevance 0

A significant increase of serum IgM together with normal values of C3 and C4 and without circulating immunocomplexes was found.

Regulation (values) of C4

6) Confidence 0.05 Published 1983 Journal Minerva Med. Section Abstract Doc Link 6408533 Disease Relevance 0.26 Pain Relevance 0.16

It may also serve as a useful prognostic marker for PCa because it is lost with increasing tumor grade and stage [47,48], and down-regulated in PCa cell lines, PC-3, LNCaP and C4-2 [37,49,50].

Regulation (regulated) of C4-2 in PC-3 associated with cancer and prostate cancer

7) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.13 Pain Relevance 0

These authors, however, used another methodology which did not enable the exclusion of an influence of endogenous C4 and C1-INH and, because of that, their results are difficult to compare with ours.

Regulation (influence) of C4

8) Confidence 0.02 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.41 Pain Relevance 0.04

Values of the C4 component in untreated and treated adults differed, being lower in the treated subjects.

Regulation (Values) of C4

9) Confidence 0.02 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.26 Pain Relevance 0

Median serum MBL concentrations, MBL pathway activity, symptom scores, and C4 levels between the various groups were compared with the Mann-Whitney U-test (rank test) because of the lack of a normal distribution.

Regulation (concentrations) of C4

10) Confidence 0.02 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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