INT23629

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Context Info
Confidence 0.40
First Reported 1986
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.81
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (fut10) Golgi apparatus (fut10)
Anatomy Link Frequency
blood 1
endothelium 1
mesangial cells 1
kidney 1
fut10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 99.44 Very High Very High Very High
Inflammation 6 99.04 Very High Very High Very High
cINOD 5 88.88 High High
anesthesia 2 61.04 Quite High
potassium channel 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 99.04 Very High Very High Very High
Renal Disease 9 97.58 Very High Very High Very High
Nephritis 3 94.88 High High
Bacterial Infection 2 93.12 High High
Injury 3 75.00 Quite High
Body Weight 1 52.88 Quite High
Hypotension 1 50.00 Quite Low
Shock 3 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This investigation examined the effects of two structurally dissimilar inhibitors of (Tx) synthetase on Salmonella enteritidis endotoxin (LPS) (15 mg/kg)-induced alterations in cardiac output and organ blood flow in Long-Evans rats.
Spec (examined) Negative_regulation (inhibitors) of Tx in blood
1) Confidence 0.40 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2425166 Disease Relevance 0.22 Pain Relevance 0.06
The duration of TxB2 inhibition was unaffected by age, possibly owing to similar relative decreases in receptor sensitivity (increased EC50) and increases in free naproxen concentrations (decreased free clearance and volume of distribution).
Negative_regulation (inhibition) of TxB2
2) Confidence 0.10 Published 1995 Journal Exp. Gerontol. Section Abstract Doc Link 8557098 Disease Relevance 0 Pain Relevance 0.07
Age had no significant effect on the pharmacodynamic parameter Emax, the maximum percent inhibition of TxB2 formation.
Negative_regulation (inhibition) of TxB2
3) Confidence 0.10 Published 1995 Journal Exp. Gerontol. Section Abstract Doc Link 8557098 Disease Relevance 0 Pain Relevance 0
Intravenous infusion of 50 mug/kg each of apamin and charybdotoxin (ChTX), a combination that is known to block Ca-activated K channels or the endothelium-derived hyperpolarization process, attenuated the decrease in MAP evoked by ghrelin in both control and NOS-inhibited rats.
Negative_regulation (decrease) of ChTX in endothelium
4) Confidence 0.03 Published 2005 Journal J. Hypertens. Section Body Doc Link 15775782 Disease Relevance 0 Pain Relevance 0
Because PGE2 preserves kidney function in glomerulonephritis, and because 12-HETE inhibits 5-lipoxygenase, the enhanced PGE2 and 12-HETE production within nephritic glomeruli after TxA2 synthase inhibition may be a superior anti-inflammatory strategy when compared with TxA2 receptor antagonism.
Negative_regulation (inhibition) of TxA2 in kidney associated with inflammation and renal disease
5) Confidence 0.02 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10560941 Disease Relevance 0.53 Pain Relevance 0.20
Because TxA2 is the most abundant eicosanoid synthesized in nephritic glomeruli, and because TxA2 synthase inhibitors and receptor antagonists are now available for the treatment of glomerulonephritis, it becomes important to address this question.
Negative_regulation (inhibitors) of TxA2 associated with antagonist and renal disease
6) Confidence 0.01 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10560941 Disease Relevance 0.50 Pain Relevance 0.23
In this study we assessed the effect of a TxA2 synthase inhibitor, Dazmegrel, and a TxA2 receptor antagonist, SQ-29 548, on glomerular PGE2, LTB4, and 12-HETE synthesis in a model of mesangial nephritis induced in the rat by the administration of a monoclonal antibody against the Thy 1.1 antigen of rat mesangial cells.
Negative_regulation (inhibitor) of TxA2 in mesangial cells associated with nephritis and antagonist
7) Confidence 0.01 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10560941 Disease Relevance 0.56 Pain Relevance 0.22

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