INT236320

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.00
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
monocyte 2
blood 1
macrophages 1
thymus 1
T cells 1
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 105 99.48 Very High Very High Very High
rheumatoid arthritis 30 99.36 Very High Very High Very High
Inflammation 114 93.48 High High
cytokine 54 81.76 Quite High
agonist 4 69.60 Quite High
Central nervous system 28 52.16 Quite High
headache 3 52.08 Quite High
Chronic pancreatitis 11 33.88 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 112 99.48 Very High Very High Very High
Rheumatoid Arthritis 30 99.36 Very High Very High Very High
Adenocarcinoma 90 99.20 Very High Very High Very High
Nicotine Addiction 91 97.36 Very High Very High Very High
Pulmonary Disease 99 94.44 High High
INFLAMMATION 125 93.48 High High
Disease 205 90.80 High High
Urological Neuroanatomy 22 89.36 High High
Viral Meningitis 4 85.84 High High
Cold Sores 367 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCR amplification of the HLA-DRB1 gene
Regulation (amplification) of HLA-DRB1
1) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0.58 Pain Relevance 0.05
Sequencing of the HLA-DRB1 Promoter in MS Patients and Controls
Regulation (Sequencing) of DRB1 associated with multiple sclerosis
2) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.38 Pain Relevance 0.19
It is plausible that a lack of vitamin D in utero or early childhood can affect the expression of HLA-DRB1 in the thymus, and impacting on central deletion.
Regulation (affect) of DRB1 in thymus
3) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.32 Pain Relevance 0.08
Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis

Background

Regulation (value) of HLA-DRB1 associated with rheumatoid arthritis
4) Confidence 0.27 Published 2008 Journal Int Arch Med Section Title Doc Link PMC2577639 Disease Relevance 0.63 Pain Relevance 0.19
Figure 3 shows the effect of 0.5 and 2 mg pretreatments with FP on O3-induced changes in the cell-surface markers CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on monocytes, macrophages, and DCs.
Regulation (effect) of HLA-DR in macrophages
5) Confidence 0.10 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.25 Pain Relevance 0
First, three sets of genes play important roles in regulating immune rejection- HLA-A, HLA-B and HLA-DR.
Regulation (regulating) of HLA-DR
6) Confidence 0.06 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2569955 Disease Relevance 0 Pain Relevance 0
There were no differences in median fluorescence intensity in NKG2 D or HLA-DR on CD8+ T cells.


Regulation (differences) of HLA-DR in T cells
7) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 2.05 Pain Relevance 0.03
Figure 3 shows the effect of 0.5 and 2 mg pretreatments with FP on O3-induced changes in the cell-surface markers CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on monocytes, macrophages, and DCs.
Regulation (effect) of HLA-DR in monocytes
8) Confidence 0.03 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.25 Pain Relevance 0
We assessed if levels of the maturation marker CD83, costimulatory molecule CD40, and HLA DR on blood MDCs and PDCs were affected by the presence of PDAC.
Regulation (affected) of HLA DR in blood associated with adenocarcinoma
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.76 Pain Relevance 0.05
Recently, it has been shown that the complex of the four glycoproteins gB, gD, gH and gL, which are essential for viral attachment/entry (Fig. 3), expressed on the surface of Cos7 cells mediates monocyte-derived DC recognition via a nucleic acid-independent and TLR-independent pathway, leading to the up-regulation of CD40, CD83, CD86 and HLA-DR and to the production of IFN-?
Regulation (regulation) of HLA-DR in monocyte
10) Confidence 0.02 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.77 Pain Relevance 0.10

General Comments

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