INT236328

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.04
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
Anatomy Link Frequency
lung 1
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 110 100.00 Very High Very High Very High
Inflammation 126 88.88 High High
cytokine 15 81.20 Quite High
corticosteroid 22 80.00 Quite High
chemokine 8 65.08 Quite High
methotrexate 18 58.76 Quite High
aspirin 3 5.20 Low Low
fibrosis 21 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
positron emission tomography 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 110 100.00 Very High Very High Very High
Disease 91 98.20 Very High Very High Very High
Apoptosis 4 95.44 Very High Very High Very High
Lung Injury 7 94.36 High High
INFLAMMATION 130 88.88 High High
Hyperplasia 1 86.36 High High
Pulmonary Disease 24 78.68 Quite High
Injury 15 78.24 Quite High
Urological Neuroanatomy 33 74.64 Quite High
Asthma 18 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a scavenger mechanism for SP-D in RA is supported by the inverse association between SP-D and disease activity measures and by the gradual SP-D increase during treatment.
Regulation (supported) of SP-D associated with rheumatoid arthritis and disease
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.93 Pain Relevance 0.32
A similar relationship was observed regarding temporal changes in SP-D and CRP (zero to four years).
Regulation (changes) of SP-D
2) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888186 Disease Relevance 0.71 Pain Relevance 0.26
The study of Takahashi et al. [13] concluded in a population of 52 IPF patients (mean follow up time 11.4 months for the subjects who died, more than 3 years for the survivors) that in the group of survivors (n = 10) the concentrations of SP-A and SP-D were within the normal range.
Regulation (concentrations) of SP-D
3) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.59 Pain Relevance 0.07
Effects of FP on 0.25 ppm O3-induced changes in serum CCP16, SP-D, eNO, and other systemic biomarkers
Regulation (changes) of SP-D
4) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.09 Pain Relevance 0.04
We have previously shown that SP-D levels in the lung are significantly altered after O3 inhalation in mice (Kierstein et al. 2006), but whether similar changes can be detected in the human serum is not known.
Regulation (altered) of SP-D in lung
5) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.57 Pain Relevance 0.07
SP-D levels were not statistically significantly altered pre-versus post-O3 exposure (mean ± SE, 61 ± 6 ng/mL vs. 55 ± 5.4 ng/mL) and were not significantly affected by 0.5 mg FP (53 ± 5 ng/mL) or 2 mg FP (64 ± 5 ng/mL) compared with placebo (55 ± 5 ng/mL).
Neg (not) Regulation (affected) of SP-D
6) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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