INT236332

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 4.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 12
blood 2
sputum 2
leukocyte 2
monocytes 2
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 43 93.60 High High
cINOD 15 83.24 Quite High
corticosteroid 17 82.04 Quite High
Inflammation 113 70.16 Quite High
pruritus 4 59.56 Quite High
rheumatoid arthritis 25 45.80 Quite Low
cytokine 78 34.00 Quite Low
headache 1 8.00 Low Low
backache 1 6.16 Low Low
methotrexate 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Cold Sores 203 99.68 Very High Very High Very High
Helminth Infection 12 99.12 Very High Very High Very High
Disease 42 98.84 Very High Very High Very High
Breast Cancer 4 98.32 Very High Very High Very High
Hookworm Infection 105 97.92 Very High Very High Very High
Hepatocellular Cancer 1 97.60 Very High Very High Very High
Adenocarcinoma 90 93.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 48 93.20 High High
Photosensitivity Disorders 27 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of an extensive data pool over multiple projects, extensive time periods and different laboratory personnel revealed a very stable basal expression of CD86 among donors (n?
Negative_regulation (revealed) of Gene_expression (expression) of CD86 in CD86
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Negative_regulation (reduced) of Gene_expression (expression) of CD86 in CD86 associated with adhesions
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.34 Pain Relevance 0.08
In contrast, non-irradiated OLQ treatment resulted in limited CD86 modulation (?
Negative_regulation (limited) of Gene_expression (modulation) of CD86 in CD86
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.17 Pain Relevance 0.07
There was a trend toward a decrease in the percentage of B cells expressing CD86 among all patients.
Negative_regulation (decrease) of Gene_expression (expressing) of CD86 in B cells
4) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833972 Disease Relevance 0.43 Pain Relevance 0
However, here we demonstrated that hookworm ES products may be partially responsible for the alternative differentiation of DC, as observed by the reduction of CD11c and CD86 expression and increase of CD80 expression on the DC surface.
Negative_regulation (reduction) of Gene_expression (expression) of CD86 in CD86 associated with hookworm infection
5) Confidence 0.29 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0.12
The rebound of CD80/CD86 expression was delayed in the HSV-2/SHIV-RT co-infected animals, although this was only evident at one time point.
Negative_regulation (delayed) of Gene_expression (expression) of CD86 in CD86 associated with cold sores
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.75 Pain Relevance 0
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Negative_regulation (decreased) of Gene_expression (expression) of CD86 in CD86 associated with helminth infection
7) Confidence 0.21 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0
In order to assess the effect of the reduced expression of CD86 and antigen presentation molecules on dendritic cells from Necator-infected patients, co-incubation with heterologous PBMCs was performed as a mixed leukocyte response.
Negative_regulation (reduced) of Gene_expression (expression) of CD86 in leukocyte
8) Confidence 0.21 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.34 Pain Relevance 0
In the present study, we found that 2 mg inhaled FP decreased the expression of CD11b, mCD14, CD16, CD64, CD86, and HLA-DR on sputum monocytic cells after O3 challenge compared with placebo treatment.
Negative_regulation (decreased) of Gene_expression (expression) of CD86 in sputum
9) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.12 Pain Relevance 0
The 0.5 mg dose of FP decreased the expression of CD86 and HLA-DR on sputum monocytes after O3 challenge compared with placebo.
Negative_regulation (decreased) of Gene_expression (expression) of CD86 in monocytes
10) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.06 Pain Relevance 0
Furthermore, impaired expression of CD80, CD86, and HLA DR by blood DC in patients with breast cancer and hepatocellular carcinoma, may have contributed to their decreased immunostimulatory capacity [22], [23].
Negative_regulation (impaired) of Gene_expression (expression) of CD86 in blood associated with hepatocellular cancer and breast cancer
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.20 Pain Relevance 0.07

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