INT236335

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 15.92
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
Anatomy Link Frequency
synovial fluid 6
epithelial cells 4
Clara cells 3
joint 1
chest 1
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
imagery 20 99.98 Very High Very High Very High
rheumatoid arthritis 880 99.84 Very High Very High Very High
Inflammation 597 99.24 Very High Very High Very High
corticosteroid 49 99.08 Very High Very High Very High
chemokine 14 96.56 Very High Very High Very High
Inflammatory mediators 42 91.80 High High
positron emission tomography 23 90.32 High High
cva 4 55.36 Quite High
Inflammatory response 42 38.40 Quite Low
Disease Link Frequency Relevance Heat
Obesity 272 100.00 Very High Very High Very High
Pleural Solitary Fibrous Tumor 58 100.00 Very High Very High Very High
Rheumatoid Arthritis 880 99.84 Very High Very High Very High
Congenital Anomalies 36 99.32 Very High Very High Very High
INFLAMMATION 612 99.24 Very High Very High Very High
Malignant Neoplastic Disease 6 99.16 Very High Very High Very High
Disorders Of The Lacrimal System 16 97.72 Very High Very High Very High
Lung Cancer 7 96.88 Very High Very High Very High
Nicotine Addiction 208 95.64 Very High Very High Very High
Sarcoma 2 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP-D is primarily synthesized by the respiratory epithelium (type II epithelial cells and Clara cells) [14,15], but is also expressed in a variety of extra-pulmonary epithelia [16].
Gene_expression (synthesized) of SP-D in Clara cells
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.60 Pain Relevance 0.16
Altered SP-D expression due to genotype abnormalities should be considered.
Gene_expression (expression) of SP-D associated with congenital anomalies
2) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.08 Pain Relevance 0.33
There was no detectable SP-D in the debris enriched pellets resulting from centrifugation of the synovial fluid.
Neg (no) Gene_expression (detectable) of SP-D in synovial fluid
3) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.32 Pain Relevance 0.09
SP-D is primarily synthesized by the respiratory epithelium (type II epithelial cells and Clara cells) [14,15], but is also expressed in a variety of extra-pulmonary epithelia [16].
Gene_expression (expressed) of SP-D in Clara cells
4) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.61 Pain Relevance 0.16
While both multimeric and trimeric subunit SP-D were present in serum, only trimeric forms could be demonstrated in synovial fluid.
Gene_expression (present) of SP-D in synovial fluid
5) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.70 Pain Relevance 0.30
Multimeric SP-D was barely detectable in synovial fluid as compared to serum, where both multimeric and trimeric molecular variant SP-D (trimeric subunits) were detected.


Gene_expression (detectable) of SP-D in synovial fluid
6) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.41 Pain Relevance 0.15
Multimeric SP-D was barely detectable in synovial fluid as compared to serum, where both multimeric and trimeric molecular variant SP-D (trimeric subunits) were detected.


Gene_expression (detected) of SP-D in synovial fluid
7) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.50 Pain Relevance 0.17
SP-D has been detected in various body fluids including serum, synovial fluid, lacrimal and broncho-alveolar lavage liquid [17-22].
Gene_expression (detected) of SP-D in lacrimal associated with disorders of the lacrimal system
8) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.42 Pain Relevance 0.10
The usual well-circumscribed appearance of the SFTP mass generally rules out malignant
Gene_expression (mass) of SFTP associated with malignant neoplastic disease and pleural solitary fibrous tumor
9) Confidence 0.57 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 1.51 Pain Relevance 0.14
correlated inversely to the SP-D change (?
Gene_expression (change) of SP-D
10) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.74 Pain Relevance 0.13
Baseline SP-D did not predict radiographic progression (Total Sharp score) at four years (P = 0.46)

SP-D in synovial fluid and corresponding sera

Gene_expression (progression) of SP-D in synovial fluid
11) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.56 Pain Relevance 0.09
Genetic SP-D variation in RA
Gene_expression (variation) of SP-D associated with rheumatoid arthritis
12) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.50 Pain Relevance 0.17
Linear regression was also applied in the prospective analysis of SP-D in RA patients, where repeated measurements in the individual patient were clustered.
Gene_expression (prospective) of SP-D associated with rheumatoid arthritis
13) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.18 Pain Relevance 0.05
This further supports that diffusion is the major source of SP-D in the joint cavity although local degradation of the molecule cannot be excluded.
Gene_expression (source) of SP-D in joint
14) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.67 Pain Relevance 0.31
The aim of our paper is to help radiologists and chest physicians to become familiar with the broad spectrum of imaging appearances of SFTP.


Spec (appearances) Gene_expression (appearances) of SFTP in chest associated with pleural solitary fibrous tumor and imagery
15) Confidence 0.45 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.69 Pain Relevance 0.14
SP-D is primarily synthesized by the respiratory epithelium (type II epithelial cells and Clara cells) [14,15], but is also expressed in a variety of extra-pulmonary epithelia [16].
Gene_expression (synthesized) of SP-D in epithelial cells
16) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.60 Pain Relevance 0.16
SP-D is primarily synthesized by the respiratory epithelium (type II epithelial cells and Clara cells) [14,15], but is also expressed in a variety of extra-pulmonary epithelia [16].
Gene_expression (expressed) of SP-D in epithelial cells
17) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.61 Pain Relevance 0.16
Serum SP-A and SP-D are hydrophilic surfactant proteins produced and secreted by type II pneumocytes.
Gene_expression (produced) of SP-D in pneumocytes
18) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.57 Pain Relevance 0.10
In turn, expression of SP-D, the protein that was originally thought to be restricted to the pulmonary compartment, was recently located in both epithelial cells of multiple mucosal surfaces and in endothelial cells [117].
Gene_expression (expression) of SP-D in epithelial cells
19) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 0.91 Pain Relevance 0.16
SP-D has been detected in various body fluids including serum, synovial fluid, lacrimal and broncho-alveolar lavage liquid [17-22].
Gene_expression (detected) of SP-D in synovial fluid associated with disorders of the lacrimal system
20) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.42 Pain Relevance 0.10

General Comments

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