INT23635

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 28.19
Pain Relevance 17.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP12) extracellular region (MMP12) proteinaceous extracellular matrix (MMP12)
Anatomy Link Frequency
macrophages 6
smooth muscle cells 4
sputum 2
alveolar macrophages 2
lymph nodes 1
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2559 100.00 Very High Very High Very High
Enkephalin 65 100.00 Very High Very High Very High
Neuropeptide 244 99.98 Very High Very High Very High
Inflammation 666 99.84 Very High Very High Very High
cytokine 369 99.32 Very High Very High Very High
substance P 7 97.94 Very High Very High Very High
cINOD 15 97.92 Very High Very High Very High
corticosteroid 112 97.36 Very High Very High Very High
Inflammatory mediators 57 92.64 High High
dexamethasone 98 92.20 High High
Disease Link Frequency Relevance Heat
Ehrlichiosis 87 100.00 Very High Very High Very High
Meningitis 46 100.00 Very High Very High Very High
Multiple Hereditary Exostoses 28 100.00 Very High Very High Very High
INFLAMMATION 785 99.84 Very High Very High Very High
Airway Remodeling 70 99.68 Very High Very High Very High
Pulmonary Disease 963 99.64 Very High Very High Very High
Emphysema 132 99.64 Very High Very High Very High
Infection 69 99.44 Very High Very High Very High
Nicotine Addiction 1102 99.12 Very High Very High Very High
Cancer 77 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results are in agreement to Demedts et al. [20], who found an increased sputum MMP-12 level in COPD patients, compared to healthy smokers, former smokers (>1 year) and never smokers, while they have not divided COPD patients into smokers and ex-smokers.
Positive_regulation (increased) of MMP-12 in sputum associated with nicotine addiction, pulmonary disease and metalloproteinase
1) Confidence 0.59 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.40 Pain Relevance 0.62
Also, according to a previous study, showing an increase in MMP-12 in the induced sputum (IS) of COPD patients [20], we have assessed an expression of MMP-12 in IS and BAL cells from these COPD and healthy subjects groups.
Positive_regulation (increase) of MMP-12 in sputum associated with pulmonary disease and metalloproteinase
2) Confidence 0.59 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 1.96 Pain Relevance 0.59
Also, Molet et al., have reported an increase of MMP-12 in BAL and bronchial biopsies of COPD patients compared to controls [30], while they have not investigated an expression of MMP-12 according to smoking status.
Positive_regulation (increase) of MMP-12 associated with nicotine addiction, pulmonary disease and metalloproteinase
3) Confidence 0.59 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.46 Pain Relevance 0.59
A significant increase in MMP-12 activity was seen following 24 hour treatment, reaching a maximal ten-fold increase after 72 hours.
Positive_regulation (increase) of MMP-12 associated with metalloproteinase
4) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.76
The induction of MMP-12 by ASMC is however unknown.
Positive_regulation (induction) of MMP-12 in ASMC associated with metalloproteinase
5) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.54 Pain Relevance 1.00
enhanced MMP-12 release from ASMC.
Positive_regulation (enhanced) of MMP-12 associated with metalloproteinase
6) Confidence 0.48 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.56 Pain Relevance 0.63
Thus, previous reports on the circulating levels of ME which relied on such procedures to stabilize the ME may have reported artifactually low values.
Positive_regulation (stabilize) of ME
7) Confidence 0.47 Published 1986 Journal Life Sci. Section Abstract Doc Link 2425209 Disease Relevance 0 Pain Relevance 0.16
Thus, we propose the use of citric acid, mixed with blood immediately upon collection, as an effective method for the stabilization of ME in blood.
Positive_regulation (stabilization) of ME in blood
8) Confidence 0.47 Published 1986 Journal Life Sci. Section Abstract Doc Link 2425209 Disease Relevance 0 Pain Relevance 0.15
Induction and regulation of matrix metalloproteinase-12in human airway smooth muscle cells

Background

Positive_regulation (Induction) of matrix metalloproteinase-12in in smooth muscle cells associated with metalloproteinase
9) Confidence 0.45 Published 2005 Journal Respir Res Section Title Doc Link PMC1363355 Disease Relevance 0.48 Pain Relevance 0.52
Macrophages with brown staining in cytoplasm were counted as MMP-12 positive macrophages (MMP-12+-macrophages) (Fig. 1A).
Positive_regulation (macrophages) of MMP-12 in macrophages associated with metalloproteinase
10) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 0.08 Pain Relevance 0.38
Also, the number of MMP-12+-macrophages was increased in both COPD groups, compared to controls.
Positive_regulation (increased) of MMP-12 in macrophages associated with pulmonary disease and metalloproteinase
11) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.73 Pain Relevance 0.60
PI3-kinase is involved in the regulation of a number of cellular responses, including MMP-12 induction in human vascular smooth muscle cells [23].
Positive_regulation (induction) of MMP-12 in smooth muscle cells associated with metalloproteinase
12) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.05 Pain Relevance 0.43
-induced MMP-12 activity (Figure 6A) and mRNA expression (Figure 6B).
Positive_regulation (induced) of MMP-12 associated with metalloproteinase
13) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.51
MMP-12 induction in human bronchial epithelial cells by TNF-?
Positive_regulation (induction) of MMP-12 in epithelial cells associated with metalloproteinase
14) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.08 Pain Relevance 0.71
Also, an increased number of BAL MMP-12+-macrophages in COPD ex-smokers, compared to 'healthy' smoking subjects, let us hypothesize that MMP-12 expression is induced not only by cigarette smoking, but may be an obligatory to the development of COPD.
Positive_regulation (increased) of MMP-12 in macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
15) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.51 Pain Relevance 0.58
Furthermore, we investigated the intracellular mechanisms of MMP-12 induction in ASMC, particularly the role of mitogen-activated protein kinases (MAPK), such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), and phosphatidylinositol 3-kinase (PI3-K) pathways.


Spec (investigated) Positive_regulation (induction) of MMP-12 associated with metalloproteinase
16) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.11 Pain Relevance 0.79
had no significant effect on MMP-12 induction.


Positive_regulation (induction) of MMP-12 associated with metalloproteinase
17) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1363355 Disease Relevance 0.56 Pain Relevance 0.65
Thus, MMP-12 induction by inflammatory cytokines may be a potential pathophysiological mechanism by which ASMC mediate and facilitate inflammatory respiratory disorders such as asthma and COPD.


Positive_regulation (induction) of MMP-12 in respiratory associated with asthma, pulmonary disease, inflammation, metalloproteinase and cytokine
18) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.42 Pain Relevance 1.06
Since inflammatory cytokines have been shown to stimulate or inhibit MMP-12 induction in macrophages [17,18] and chondrocytes [19]), we examined the possible effects of the inflammatory cytokines, including interleukin (IL)-1?
Positive_regulation (induction) of MMP-12 in chondrocytes associated with inflammation, metalloproteinase and cytokine
19) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.49 Pain Relevance 1.02
-mediated MMP-12 induction in macrophages [18].
Positive_regulation (induction) of MMP-12 in macrophages associated with metalloproteinase
20) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.05 Pain Relevance 0.76

General Comments

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