INT236350

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 15
Disease Relevance 3.59
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
NK cells 3
T cells 3
blood cells 2
monocytes 1
leukocytes 1
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 310 99.40 Very High Very High Very High
chemokine 117 71.24 Quite High
Hippocampus 3 66.12 Quite High
cytokine 38 50.52 Quite High
Spinal cord 28 42.80 Quite Low
Multiple sclerosis 29 33.00 Quite Low
imagery 42 32.96 Quite Low
Neurobehavioral 14 17.00 Low Low
cINOD 5 16.40 Low Low
Central nervous system 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 309 99.76 Very High Very High Very High
INFLAMMATION 327 99.40 Very High Very High Very High
Multiple Sclerosis 631 91.80 High High
Targeted Disruption 198 87.36 High High
Amyloid Plaque 7 77.52 Quite High
Disorder Of Lipid Metabolism 14 76.16 Quite High
Increased Venous Pressure Under Development 14 72.48 Quite High
Peritonitis 98 68.04 Quite High
Aids-related Complex 14 62.48 Quite High
Disease Progression 1 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reactions were run in quadruplicate, and CCR2 and RFP mRNA expression levels were normalized to beta-actin.


Transcription (expression) of CCR2
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0
Thus, Ly6Clo monocytes transcribe CCR2 but fail to translate it into protein.
Transcription (transcribe) of CCR2 in monocytes
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.09
Differential distribution of CX3CR1 and CCR2 in the naive and inflamed brain
Transcription (distribution) of CCR2 in brain
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.23 Pain Relevance 0
In blood cells from Ccr2RFP/+ mice, CCR2 and RFP mRNA levels tracked closely, as expected for bi-allelic expression from the CCR2 promoter (Figure 2A).
Transcription (levels) of CCR2 in blood cells
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0 Pain Relevance 0
In blood cells from Ccr2RFP/+ mice, CCR2 and RFP mRNA levels tracked closely, as expected for bi-allelic expression from the CCR2 promoter (Figure 2A).
Transcription (levels) of Ccr2RFP in blood cells
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0 Pain Relevance 0
Similarly, intracellular CCR2 was undetectable in T cells or NK cells, despite the presence of CCR2 mRNA (data not shown).
Transcription (presence) of CCR2 in NK cells
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0.04
The expression of CCR2 transcripts in some NK and T cells is of interest and must be taken into account when using this model.


Transcription (expression) of CCR2 in T cells
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.42 Pain Relevance 0.09
Reactions were run in quadruplicate, and CCR2 and RFP mRNA expression levels were normalized to beta-actin.


Transcription (levels) of CCR2
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0
CCR2 and RFP transcript levels were determined by quantitative RT-PCR of cell populations isolated by fluorescence-activated cell sorting (FACS).
Transcription (levels) of CCR2
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.06 Pain Relevance 0
Despite lacking CCR2 immunoreactivity by flow cytometry, T cells and NK cells from WT and Ccr2RFP/+ mice contained CCR2 transcripts, and CCR2 and RFP mRNA levels were similar in both cell types (Figure 2B).
Transcription (levels) of CCR2 in T cells
10) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.16 Pain Relevance 0.04
Some CCR2 surface-negative leukocytes contained abundant levels of CCR2 mRNA (and RFP protein and mRNA) (Figure 2).
Transcription (levels) of CCR2 in leukocytes
11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.23 Pain Relevance 0.04
Despite lacking CCR2 immunoreactivity by flow cytometry, T cells and NK cells from WT and Ccr2RFP/+ mice contained CCR2 transcripts, and CCR2 and RFP mRNA levels were similar in both cell types (Figure 2B).
Transcription (levels) of CCR2 in T cells
12) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.16 Pain Relevance 0.04
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Transcription (receptor) of CCR2 in microglia
13) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.99 Pain Relevance 0.09
Despite lacking CCR2 immunoreactivity by flow cytometry, T cells and NK cells from WT and Ccr2RFP/+ mice contained CCR2 transcripts, and CCR2 and RFP mRNA levels were similar in both cell types (Figure 2B).
Transcription (levels) of CCR2 in NK cells
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.16 Pain Relevance 0.04
Despite lacking CCR2 immunoreactivity by flow cytometry, T cells and NK cells from WT and Ccr2RFP/+ mice contained CCR2 transcripts, and CCR2 and RFP mRNA levels were similar in both cell types (Figure 2B).
Transcription (levels) of CCR2 in NK cells
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.16 Pain Relevance 0.04

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