INT236354

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.19
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cardiomyocytes 2
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 12 90.92 High High
Multiple sclerosis 1 63.76 Quite High
cytokine 38 54.48 Quite High
Inflammation 9 48.92 Quite Low
Inflammatory response 3 40.88 Quite Low
chemokine 19 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 127 99.40 Very High Very High Very High
Myocardial Infarction 49 97.86 Very High Very High Very High
Apoptosis 3 92.72 High High
Cv Unclassified Under Development 11 90.92 High High
Reperfusion Injury 5 67.32 Quite High
Multiple Sclerosis 1 66.36 Quite High
Demyelinating Disease 1 63.76 Quite High
Autoimmune Disease 2 62.68 Quite High
Targeted Disruption 17 50.00 Quite Low
INFLAMMATION 14 48.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CCR2-deficient or C3 inhibitor-overexpressing mice, however, an increase in A?
Negative_regulation (inhibitor) of Negative_regulation (deficient) of C3
1) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.14 Pain Relevance 0.06
In a rat model of MI, C1-INH suppressed C3 mRNA expression and protein synthesis, while in cultured rat cardiomyocytes, C1-INH blocked deposition of C3 (Fu et al 2006b).
Negative_regulation (blocked) of Negative_regulation (deposition) of C3 in cardiomyocytes associated with myocardial infarction
2) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.05 Pain Relevance 0.15

General Comments

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