INT236356

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.20
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
microglia 3
neuronal 2
astrocyte 1
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 92.56 High High
Kappa opioid receptor 80 89.04 High High
Peripheral nervous system 16 88.16 High High
Multiple sclerosis 3 76.04 Quite High
trigeminal ganglion 22 74.28 Quite High
cytokine 86 66.76 Quite High
Inflammation 117 50.00 Quite Low
Opioid 15 50.00 Quite Low
Dynorphin 8 31.84 Quite Low
allodynia 9 28.28 Quite Low
Disease Link Frequency Relevance Heat
Disease 245 98.96 Very High Very High Very High
Injury 9 97.52 Very High Very High Very High
Congenital Anomalies 43 96.64 Very High Very High Very High
Neurologic Manifestations 12 87.28 High High
Multiple Sclerosis 2 78.64 Quite High
Demyelinating Disease 8 76.04 Quite High
Autoimmune Disease 2 74.96 Quite High
Ganglion Cysts 24 74.28 Quite High
Gliosis 11 64.24 Quite High
INFLAMMATION 130 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such neuronal cell loss was suggested by the brain MRI studies and the increase of GFAP message in the full genome microarrays which reflected neuronal cell injury (see below).
Positive_regulation (increase) of GFAP Binding (message) of in neuronal associated with injury
1) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.42 Pain Relevance 0
Quantification showed that pIONL significantly increased the intensity of GFAP-IR in ipsilateral TREZ in WT mice compared with sham operated mice or with the contralateral TREZ (Fig. 4A, B, C, F).
Positive_regulation (increased) of GFAP-IR Binding (intensity) of
2) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.20 Pain Relevance 0.47
Immunoreactivity for CD11b and GFAP, markers for activated microglia and astrocyte, respectively, increased in 13–15 month-old TLR4m AD mice compared to TLR4w AD mice.
Positive_regulation (increased) of GFAP Binding (Immunoreactivity) of in microglia associated with disease
3) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.29 Pain Relevance 0.10
Immunoreactivity for CD11b and GFAP, markers for activated microglia and astrocyte, respectively, increased in 13–15 month-old TLR4m AD mice compared to TLR4w AD mice.
Positive_regulation (increased) of GFAP in astrocyte Binding (Immunoreactivity) of in microglia associated with disease
4) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.29 Pain Relevance 0.10

General Comments

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