INT23638

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1986
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 5.68
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
LES 6
leukocytes 2
tears 1
smooth muscle 1
nerves 1
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 36 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
c fibre 4 100.00 Very High Very High Very High
tetrodotoxin 10 99.44 Very High Very High Very High
Dopamine 1 99.38 Very High Very High Very High
Calcitonin gene-related peptide 1 98.68 Very High Very High Very High
antagonist 2 96.64 Very High Very High Very High
opiate 1 96.64 Very High Very High Very High
Serotonin 2 95.72 Very High Very High Very High
Pain 7 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fabry Disease 29 99.66 Very High Very High Very High
Lysosome Storage Disease 2 98.28 Very High Very High Very High
Pressure And Volume Under Development 2 94.12 High High
Angiokeratoma 10 92.72 High High
Disease 14 88.96 High High
Natriuresis 1 86.08 High High
Pain 7 84.40 Quite High
Increased Venous Pressure Under Development 2 81.20 Quite High
Hypohidrosis 2 78.24 Quite High
Corneal Opacity 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects of galanin were not inhibited by either atropine (5 x 10(-6) M) or tetrodotoxin (3 x 10(-6) M).
Negative_regulation (inhibited) of galanin associated with tetrodotoxin
1) Confidence 0.42 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595426 Disease Relevance 0.06 Pain Relevance 0.33
Fabry Disease (FD) is an X-linked lysosomal storage disorder (prevalence about 1 : 100 000) caused by a genetic defect associated with a lack of alpha-galactosidase A (alpha-GAL) enzyme activity.
Negative_regulation (lack) of GAL associated with fabry disease and lysosome storage disease
2) Confidence 0.42 Published 2005 Journal Fortschr Neurol Psychiatr Section Abstract Doc Link 16283613 Disease Relevance 1.05 Pain Relevance 0.18
Stimulatory molecules include serotonin, arginine-vasotocin, tachykinins, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide; inhibitory molecules are dopamine, somatotropic hormone-release inhibiting hormone and galanin.
Negative_regulation (inhibiting) of galanin in pituitary associated with dopamine, serotonin and calcitonin gene-related peptide
3) Confidence 0.42 Published 1998 Journal Histol. Histopathol. Section Abstract Doc Link 9476650 Disease Relevance 0.09 Pain Relevance 0.38
This paper reviews natural history of three unrecognized cases recently diagnosed by markedly deficient alpha galactosidase A (alpha Gal A) activity in peripheral leucocytes.
Negative_regulation (deficient) of Gal in leucocytes
4) Confidence 0.41 Published 2006 Journal Rom J Intern Med Section Abstract Doc Link 17236300 Disease Relevance 1.41 Pain Relevance 0.15
A deficiency of alpha-gal A in serum, leukocytes, tears, tissue specimens, or cultured skin fibroblasts further supports the diagnosis in male patients.
Negative_regulation (deficiency) of gal in tears
5) Confidence 0.41 Published 2003 Journal Am J Clin Dermatol Section Abstract Doc Link 12627994 Disease Relevance 0.89 Pain Relevance 0.10
The effect of GMAP on the baseline reflex was similar in normal and axotomized rats, but the blocking effect of GMAP on C-fiber CS-induced facilitation was significantly reduced after axotomy.
Negative_regulation (blocking) of GMAP associated with c fibre
6) Confidence 0.35 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7603589 Disease Relevance 0.14 Pain Relevance 0.64
The effect of GMAP on the baseline reflex was similar in normal and axotomized rats, but the blocking effect of GMAP on C-fiber CS-induced facilitation was significantly reduced after axotomy.
Negative_regulation (reduced) of GMAP associated with c fibre
7) Confidence 0.35 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7603589 Disease Relevance 0.14 Pain Relevance 0.64
Interestingly, neither M15 nor M35 (up to 10(-7) M) were able to inhibit the responses of the smooth muscle to galanin.
Negative_regulation (inhibit) of galanin in smooth muscle
8) Confidence 0.31 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595426 Disease Relevance 0.08 Pain Relevance 0.36
Fabry disease is an inherited deficiency of the lysosomal hydrolase alpha-galactosidase A (alpha GalA) due to mutations in the Gal gene at Xq22.
Negative_regulation (deficiency) of Gal gene associated with fabry disease
9) Confidence 0.20 Published 2004 Journal Joint Bone Spine Section Abstract Doc Link 15474388 Disease Relevance 0.94 Pain Relevance 0.08
Since tetrodotoxin blockade of nerves did not reduce the response and galanin at 10(-10) mols was able to eliminate the smooth muscle response to intraarterial acetylcholine, we suggest that galanin acts to inhibit smooth muscle directly.
Neg (not) Negative_regulation (reduce) of galanin in nerves associated with tetrodotoxin
10) Confidence 0.20 Published 1986 Journal Life Sci. Section Abstract Doc Link 2425211 Disease Relevance 0 Pain Relevance 0.42
A deficiency of alpha-gal A in serum, leukocytes, tears, tissue specimens, or cultured skin fibroblasts further supports the diagnosis in male patients.
Negative_regulation (deficiency) of gal in leukocytes
11) Confidence 0.14 Published 2003 Journal Am J Clin Dermatol Section Abstract Doc Link 12627994 Disease Relevance 0.89 Pain Relevance 0.10
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
12) Confidence 0.04 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.26
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
13) Confidence 0.04 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.23
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
14) Confidence 0.04 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.26
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
15) Confidence 0.04 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.35
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
16) Confidence 0.04 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.34
The aims of this study were to determine: (1) the distribution of galanin at the feline LES; (2) the effect of galanin on basal LES tone; (3) the effect of galanin on agonist-induced LES contractions by BN, SP and bethanechol; and (4) the effect of galanin on LES relaxation induced by esophageal distension and exogenous VIP.
Negative_regulation (effect) of galanin in LES associated with agonist and substance p
17) Confidence 0.03 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7517056 Disease Relevance 0 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox