INT2364

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Context Info
Confidence 0.80
First Reported 1976
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 134
Total Number 136
Disease Relevance 26.21
Pain Relevance 41.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
pancreas 7
plasma 4
neural 3
nerve 3
Gut 2
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 160 100.00 Very High Very High Very High
qutenza 98 100.00 Very High Very High Very High
Bile 30 100.00 Very High Very High Very High
anesthesia 29 100.00 Very High Very High Very High
Dopamine 28 100.00 Very High Very High Very High
Cholecystokinin 25 100.00 Very High Very High Very High
Serotonin 13 100.00 Very High Very High Very High
Chronic pancreatitis 80 99.96 Very High Very High Very High
gABA 94 99.84 Very High Very High Very High
GABAergic 16 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperinsulinism 2 100.00 Very High Very High Very High
Pancreatic Cancer 5 99.98 Very High Very High Very High
Pancreatitis 96 99.96 Very High Very High Very High
Diabetes Mellitus 39 99.84 Very High Very High Very High
Nicotine Addiction 8 99.68 Very High Very High Very High
Pain 8 99.64 Very High Very High Very High
Protein Deficiency 2 99.62 Very High Very High Very High
Shock 1 99.60 Very High Very High Very High
Vomiting 4 99.40 Very High Very High Very High
Duodenal Ulcer 37 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of specific channel blockers further revealed that L-type and P/Q-type calcium channels underlie both basal and KCl-evoked secretin release.
Localization (release) of secretin associated with calcium channel
1) Confidence 0.80 Published 2005 Journal Neuroscience Section Abstract Doc Link 15963647 Disease Relevance 0 Pain Relevance 0.42
First, to show that secretin is released endogenously, blocks of freshly dissected cerebella were challenged with a high concentration of KCl.
Localization (released) of secretin
2) Confidence 0.80 Published 2005 Journal Neuroscience Section Abstract Doc Link 15963647 Disease Relevance 0 Pain Relevance 0.18
On the other hand, although the response of secretin release in diabetes mellitus was also lower compared with that in control group, the capacity of secretin response showed values in-between control subjects and chronic pancreatitis.
Localization (release) of secretin associated with diabetes mellitus and chronic pancreatitis
3) Confidence 0.80 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.91 Pain Relevance 0.34
Impaired secretin release and reduced duodenal S-cells have been documented in peptic ulcer patients compared with control patients.
Localization (release) of secretin associated with ulcers
4) Confidence 0.80 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.80 Pain Relevance 0.12
Secretin is released into the circulation from the S-cells of the duodenal crypts in response to gastric acid entering the duodenum.
Localization (released) of Secretin in duodenum
5) Confidence 0.80 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.46 Pain Relevance 0.13
Both in chronic and acute experiments the degenerated right cervical vagus nerve was stimulated by electrical shock and the endogenous secretin and CCK was released by means of duodenal acidification (D.
Localization (released) of secretin in vagus nerve associated with shock and vagus nerve
6) Confidence 0.79 Published 1991 Journal Sci. China, Ser. B, Chem. Life Sci. Earth Sci. Section Abstract Doc Link 1888435 Disease Relevance 0.29 Pain Relevance 0.20
Effects of intrapancreatic cholinergic activation by electrical field stimulation (EFS) on secretin-stimulated pancreatic exocrine secretion were investigated in the totally isolated perfused rat pancreas.
Spec (investigated) Localization (secretion) of secretin in pancreas
7) Confidence 0.78 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486197 Disease Relevance 0 Pain Relevance 0.08
Significant cholinergic role in secretin-stimulated exocrine secretion in isolated rat pancreas.
Localization (secretion) of secretin in pancreas
8) Confidence 0.78 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9486197 Disease Relevance 0.06 Pain Relevance 0.12
In conclusion, the activation of intrapancreatic cholinergic neurons potentiated the secretin action on pancreatic exocrine secretion in the rat.
Localization (secretion) of secretin in cholinergic neurons
9) Confidence 0.78 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486197 Disease Relevance 0.09 Pain Relevance 0.16
In conclusion, the release and action of both SRP and secretin are mediated by a vagal afferent pathway. beta-Adrenergic receptors also play a significant role in the release of SRP.
Localization (release) of secretin
10) Confidence 0.76 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.49
Neuronal regulation of the release and action of secretin-releasing peptide and secretin.
Localization (release) of secretin in Neuronal associated with qutenza
11) Confidence 0.76 Published 1995 Journal Am. J. Physiol. Section Title Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.43
Both release of secretin and pancreatic exocrine secretion (PES) elicited by duodenal acidification were also inhibited dose-dependently by Met-enkepahlin, 5-HT(2) antagonist, ketanserin and 5-HT(3) antagonist, ondansetron.
Localization (release) of secretin associated with antagonist
12) Confidence 0.75 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.70
However, the neuropeptides and neurotransmitters involved in regulation of the release and action of secretin and their sites of action remain to be elucidated.
Localization (release) of secretin associated with neurotransmitter and neuropeptide
13) Confidence 0.75 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.29
The release of secretin by SRP was abolished in rats treated with TTX, mucosal or perivagal application of capsaicin, MEK or vagotomy.
Localization (release) of secretin associated with qutenza and enkephalin
14) Confidence 0.75 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.62
Neural control of the release and action of secretin.
Localization (release) of secretin in Neural
15) Confidence 0.75 Published 2003 Journal J. Physiol. Pharmacol. Section Title Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.50
Secretin is a stimulator of both endocrine and exocrine secretions of the pancreas, and we aimed to evaluate its effects on splanchnic blood flow in rats with a microsphere technique.
Localization (secretions) of Secretin in pancreas
16) Confidence 0.75 Published 2001 Journal World J Surg Section Abstract Doc Link 11572020 Disease Relevance 0.16 Pain Relevance 0
It has become clear that secretin is a hormone-regulating pancreatic exocrine secretion of fluid and bicarbonate, gastric acid secretion, and gastric motility.
Localization (secretion) of secretin
17) Confidence 0.75 Published 2003 Journal J. Gastroenterol. Section Abstract Doc Link 14673718 Disease Relevance 0 Pain Relevance 0.08
The neural regulatory mechanisms of the release and action of secretin await further elucidation.
Localization (release) of secretin in neural
18) Confidence 0.75 Published 2003 Journal J. Gastroenterol. Section Abstract Doc Link 14673718 Disease Relevance 0 Pain Relevance 0.17
For each agent and for secretin alone in normal and vagotomized dogs, a comparison was made of pancreatic secretion with and without lignocaine anesthesia of the duodenal mucosa.
Localization (secretion) of secretin associated with anesthesia
19) Confidence 0.74 Published 1985 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 4020032 Disease Relevance 0.05 Pain Relevance 0.26
Sequential studies were performed on pancreatic secretion in response to secretin and on parotid secretion in response to urecholine.
Localization (secretion) of secretin
20) Confidence 0.74 Published 1978 Journal Am. J. Gastroenterol. Section Abstract Doc Link 717366 Disease Relevance 0.33 Pain Relevance 0.12

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