INT236400

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.84
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retina 2
astrocytes 1
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 15 94.16 High High
antagonist 12 82.92 Quite High
imagery 46 53.28 Quite High
Inflammation 11 50.00 Quite Low
cytokine 8 18.80 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 1 99.98 Very High Very High Very High
Diabetes Mellitus 110 98.16 Very High Very High Very High
Glioma 29 97.60 Very High Very High Very High
Papilledema 2 95.84 Very High Very High Very High
Diabetic Macular Edema 42 84.56 Quite High
Cancer 148 80.16 Quite High
Injury 6 79.44 Quite High
Fibromyalgia 4 67.64 Quite High
INFLAMMATION 18 50.00 Quite Low
Frailty 2 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Neg (not) Regulation (alter) of FLT-1 in retina
1) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.67 Pain Relevance 0.05
No VEGFR-1 immunoreactivity was observed with GFAP (+)ve astrocytes (data not shown).
Neg (No) Regulation (immunoreactivity) of VEGFR-1 in astrocytes
2) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0 Pain Relevance 0.04
Intravitreal injection of TA stabilizes the BRB in association with regulation of Vegf-a, Flk-1, and Flt-1 expression in retinas in the early stages of diabetes.



Regulation (regulation) of Flt-1 in retinas associated with diabetes mellitus
3) Confidence 0.11 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.61 Pain Relevance 0
Anti-angiogenic treatments of malignant tumors targeting vascular endothelial growth factor receptors (VEGFR) tyrosine kinase are being used in different early stages of clinical trials.
Regulation (targeting) of VEGFR associated with malignant neoplastic disease
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806917 Disease Relevance 0.56 Pain Relevance 0.05

General Comments

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