INT236437

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARHGAP8) signal transduction (ARHGAP8) intracellular (ARHGAP8)
ARHGAP8 (Homo sapiens)
ARHGAP8 - P610T (2)
Pain Link Frequency Relevance Heat
Nav1.7 30 99.60 Very High Very High Very High
Pain 40 93.96 High High
hypoalgesia 4 91.36 High High
Congenital analgesia 6 89.12 High High
sodium channel 8 67.28 Quite High
alcohol 2 42.40 Quite Low
Paroxysmal extreme pain disorder 16 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 28 93.96 High High
Hypoalagesia 4 91.36 High High
Congenital Pain Insensitivity 6 89.12 High High
Erythermalgia 26 75.36 Quite High
Hyperalgesia 4 59.84 Quite High
Hypothermia 4 59.64 Quite High
Disease 4 59.40 Quite High
Somatoform Disorder 16 5.00 Very Low Very Low Very Low
Diarrhoea 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, P610T may be a loss of function (lof) allele.
Negative_regulation (loss) of P610T (P610T)
1) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430949 Disease Relevance 0.63 Pain Relevance 0.90
Somewhat surprisingly however, the second variant, P610T, is shared by the proband and the unaffected but not the affected siblings.
Negative_regulation (shared) of P610T (P610T)
2) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430949 Disease Relevance 0.25 Pain Relevance 0.17

General Comments

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