INT236441

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARHGAP8) signal transduction (ARHGAP8) intracellular (ARHGAP8)
ARHGAP8 (Homo sapiens)
ARHGAP8 - P610T (1)
Pain Link Frequency Relevance Heat
Nav1.7 30 89.12 High High
Pain 40 75.92 Quite High
sodium channel 8 57.12 Quite High
hypoalgesia 4 53.36 Quite High
Congenital analgesia 6 51.12 Quite High
Paroxysmal extreme pain disorder 16 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 90.68 High High
Pain 28 75.92 Quite High
Erythermalgia 26 65.44 Quite High
Hypoalagesia 4 53.36 Quite High
Congenital Pain Insensitivity 6 51.12 Quite High
Hyperalgesia 4 21.84 Low Low
Somatoform Disorder 16 5.00 Very Low Very Low Very Low
Hypothermia 4 5.00 Very Low Very Low Very Low
Diarrhoea 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P610 is located within the cytosolic linker joining transmembrane segment S6 of domain I and transmembrane segment S1 of domain II and appears to be located within a conserved region of SCN9a.
Localization (located) of P610
1) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430949 Disease Relevance 0.26 Pain Relevance 0.17
Moreover, we found P610T in 10 out of 210 control Caucasian chromosomes.
Localization (found) of P610T (P610T)
2) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430949 Disease Relevance 0.31 Pain Relevance 0.38

General Comments

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