INT236453

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.95
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 23 95.16 Very High Very High Very High
dopaminergic neurodegeneration 5 92.80 High High
Substantia nigra 37 89.80 High High
Inflammatory response 6 84.72 Quite High
Dopamine 6 41.72 Quite Low
midbrain 3 38.84 Quite Low
ischemia 5 18.68 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 48 99.20 Very High Very High Very High
INFLAMMATION 29 95.16 Very High Very High Very High
Burns 36 95.12 Very High Very High Very High
Adhesions 7 89.04 High High
Disease 29 84.00 Quite High
Stress 2 68.24 Quite High
Toxicity 1 63.52 Quite High
Urological Neuroanatomy 12 52.80 Quite High
Nephrotoxicity 1 21.04 Low Low
Reperfusion Injury 4 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo administration of CORM-2 was able to inhibit the upregulation of ICAM-1 induced by thermal injury.
Negative_regulation (inhibit) of Positive_regulation (upregulation) of ICAM-1 associated with injury
1) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.71 Pain Relevance 0.24
R blocks the transcriptional induction of p65, p50, and ICAM-1, prevents microglial p65 accumulation.
Negative_regulation (blocks) of Positive_regulation (induction) of ICAM-1
2) Confidence 0.20 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.24 Pain Relevance 0.14

General Comments

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