INT23646

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.80
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scnn1a) plasma membrane (Scnn1a)
Anatomy Link Frequency
N-18 1
nephron 1
Scnn1a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1 100.00 Very High Very High Very High
tetrodotoxin 2 92.72 High High
Inflammation 18 84.28 Quite High
anesthesia 9 69.12 Quite High
Glutamate receptor 1 66.68 Quite High
fibrosis 19 40.60 Quite Low
qutenza 3 33.60 Quite Low
Calcium channel 2 28.40 Quite Low
antagonist 1 25.12 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 61 99.92 Very High Very High Very High
Heart Rate Under Development 2 89.60 High High
Edema 33 86.32 High High
Neuroblastoma 4 84.68 Quite High
Cancer 2 84.56 Quite High
INFLAMMATION 23 84.28 Quite High
Apoptosis 1 83.64 Quite High
Solid Tumor 1 82.28 Quite High
Targeted Disruption 4 75.00 Quite High
Disease 7 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophysiological and immunohistochemical studies under high K+ diet indicated that reduced epithelial Na+ channel ENaC and/or Na+/K+-ATPase activity in the aldosterone-sensitive distal nephron accounted for the impaired response in sgk1-/- and that an enhanced apical abundance of renal outer medullary K+ channel ROMK partly compensated for the defect.
Negative_regulation (reduced) of ENaC in nephron
1) Confidence 0.57 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 15034090 Disease Relevance 0.14 Pain Relevance 0.07
In some mammals degenerin/epithelial Na+ channels (DEG/ENaC) are known to be suppressed by the inhibitor amiloride.
Negative_regulation (suppressed) of ENaC
2) Confidence 0.41 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2896210 Disease Relevance 0 Pain Relevance 0.03
Treatment of N-18 cells with 10 microM swainsonine for 24 h markedly reduced the activity of the neurotoxin-responsive Na+ channel, as shown by the neurotoxin-stimulated efflux of 86Rb in vivo.
Negative_regulation (reduced) of Na+ channel in N-18
3) Confidence 0.36 Published 1986 Journal Carbohydr. Res. Section Abstract Doc Link 2425966 Disease Relevance 0.13 Pain Relevance 0.09
All of these compounds inhibited the activity of the neurotoxin-responsive Na+ channel with the exception of retinoic acid which increased the activity.
Negative_regulation (inhibited) of Na+ channel
4) Confidence 0.36 Published 1986 Journal Carbohydr. Res. Section Abstract Doc Link 2425966 Disease Relevance 0.16 Pain Relevance 0.06
Moreover, these proteasome inhibitors were also effective in suppressing functional epithelial sodium channel (ENaC) activity and currents independent of CFTR vector administration [6].
Negative_regulation (suppressing) of ENaC associated with sodium channel
5) Confidence 0.09 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.56 Pain Relevance 0.09
For the level of hypoxia induced, no changes in AQP5 were found by western blotting (data not shown) and furthermore other data suggest that in mild hypoxia no inhibition of ENaC channels was found [31,32].


Negative_regulation (inhibition) of ENaC associated with hypoxia
6) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1363731 Disease Relevance 0.81 Pain Relevance 0

General Comments

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