INT236467

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRPB) extracellular matrix organization (MMP9) protein complex (MMP9)
cytoplasm (SNRPB) cytosol (SNRPB) extracellular space (MMP9)
Anatomy Link Frequency
ear 1
MMP9 (Homo sapiens)
SNRPB (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 99.16 Very High Very High Very High
Inflammatory mediators 2 41.04 Quite Low
cytokine 4 31.32 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Junctional Epidermolysis Bullosa 3 97.44 Very High Very High Very High
Blister 14 87.68 High High
Lung Injury 3 53.92 Quite High
INFLAMMATION 20 41.04 Quite Low
Bullous Skin Disease 1 37.40 Quite Low
Injury 16 35.32 Quite Low
Death 13 16.08 Low Low
Apoptosis 12 5.76 Low Low
Necrosis 8 5.00 Very Low Very Low Very Low
Poisoning 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it has been shown that, for example, matrix-metalloproteinases are main players in skin pathology of SM-induced blisters84,85 and in JEB.86 Studies with the mouse ear model furthermore suggest that matrix metalloproteinase-9 (MMP-9) is the most upregulated MMP in SM exposed skin.84 Neutrophil-derived MMP-9 inactivates ?
MMP-9 Negative_regulation (inactivates) of SM in ear associated with junctional epidermolysis bullosa and metalloproteinase
1) Confidence 0.01 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.45 Pain Relevance 0.10

General Comments

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