INT236485

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 142 100.00 Very High Very High Very High
GCH1 2 98.84 Very High Very High Very High
nociceptor 5 86.00 High High
Catecholamine 1 66.00 Quite High
Serotonin 1 65.24 Quite High
Tetrahydrobiopterin 1 63.48 Quite High
Endocannabinoid 1 59.12 Quite High
Opioid 9 55.64 Quite High
analgesia 7 50.60 Quite High
Analgesic 9 39.52 Quite Low
Disease Link Frequency Relevance Heat
Pain 148 100.00 Very High Very High Very High
Nociception 11 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Burns 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subjects heterozygous or
               homozygous for the pain-protective haplotype were found to show reduced upregulation
               of the GCH1 transcript in response to cAMP, resulting in lower
               levels of BH4, suggesting that altered GCH1 transcriptional
               modulation underlies the decreased pain sensitivity observed in these individuals.
Negative_regulation (decreased) of Regulation (sensitivity) of pain associated with pain and gch1
1) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.76 Pain Relevance 1.23

General Comments

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