INT236487

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Grina) cellular_component (Grina) biological_process (Grina)
Anatomy Link Frequency
forebrain 2
Grina (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
IPN 2 99.92 Very High Very High Very High
Pain 152 99.24 Very High Very High Very High
Neuropeptide 1 98.50 Very High Very High Very High
Cancer pain 17 97.16 Very High Very High Very High
long-term potentiation 1 80.80 Quite High
c fibre 15 71.04 Quite High
Acute pain 1 61.28 Quite High
Neuropathic pain 4 55.68 Quite High
Inflammation 10 54.84 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.92 Very High Very High Very High
Pain 160 99.24 Very High Very High Very High
Bone Cancer 41 99.00 Very High Very High Very High
Targeted Disruption 7 85.88 High High
Sprains And Strains 5 78.72 Quite High
Nociception 14 75.96 Quite High
Disease 7 68.76 Quite High
Cancer 75 68.52 Quite High
Neuropathic Pain 13 55.68 Quite High
INFLAMMATION 13 54.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In bone cancer models pain-related behaviors are accompanied by increased expression of NR2B, an NMDA receptor subunit.
Positive_regulation (increased) of Gene_expression (expression) of NMDA receptor subunit associated with pain, nmda receptor and bone cancer
1) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.61 Pain Relevance 0.60
Examples of transgenics that have generated
               insights into pain pathways are numerous, and include reports of modulation of pain
               behaviour by the overexpression of the neuropeptide galanin [28], and the enhancement of
               inflammatory pain by overexpression of the NMDA receptor subunit N2RB in the
               forebrain [29]. 
Positive_regulation (overexpression) of Gene_expression (overexpression) of NMDA receptor subunit in forebrain associated with pain, nmda receptor, ipn and neuropeptide
2) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.16 Pain Relevance 0.85

General Comments

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