INT236490

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN11A) transmembrane transport (SCN11A)
Anatomy Link Frequency
neurons 1
SCN11A (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.8 9 100.00 Very High Very High Very High
tetrodotoxin 10 99.42 Very High Very High Very High
Nav1.9 4 99.36 Very High Very High Very High
sodium channel 17 97.28 Very High Very High Very High
Nav1.7 7 96.72 Very High Very High Very High
Pain 143 95.60 Very High Very High Very High
Nav1.6 7 95.36 Very High Very High Very High
nav1.3 7 92.96 High High
Nav1.2 5 91.76 High High
Nav1.1 8 90.56 High High
Disease Link Frequency Relevance Heat
Pain 149 95.60 Very High Very High Very High
Targeted Disruption 7 95.36 Very High Very High Very High
INFLAMMATION 6 79.12 Quite High
Sperm Disorder 15 47.20 Quite Low
Inflammatory Pain 2 46.24 Quite Low
Loss Of Sense Of Smell 1 30.64 Quite Low
Nociception 12 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunits are inhibited by TTX in the micromolar range and include SCN5A (also known as Nav1.5), SCN10A (also known as Nav1.8), and SCN11A (also known as Nav1.9) [2,5].
Positive_regulation (include) of SCN11A associated with tetrodotoxin, nav1.8 and nav1.9
1) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.30
One, SCN11A, is found in a subset of
               damage-sensing neurons, and is activated close to the resting membrane potential.
               
Positive_regulation (activated) of SCN11A in neurons
2) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.91 Pain Relevance 1.07

General Comments

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