INT236519

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mutyh) hydrolase activity, acting on glycosyl bonds (Mutyh) nucleus (Mutyh)
Anatomy Link Frequency
plasma 2
Mutyh (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 12 91.76 High High
depression 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Night Blindness 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Eye Disease 2 5.00 Very Low Very Low Very Low
Rod Or Cone Dystrophy 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While we did not map the exact residues in this 20 amino acid region necessary for this interaction, these data suggest that the CSNB2-like phenotype of the Cacna1fnob2 mouse may result not only from lower Cav1.4-mediated calcium-current densities, due to the diminished production of full-length protein, but also to a failure of targeting of the mutant protein to the plasma membrane, due to its inability to interact with filamin.
Negative_regulation (diminished) of Gene_expression (production) of full-length protein in plasma
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
Because of their highly repetitive sequence, transposable elements have previously been shown to undergo alternative splicing; this allows for full-length protein to be produced, albeit at reduced levels relative to those in WT controls [26], [27].
Negative_regulation (reduced) of Gene_expression (produced) of full-length protein
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0.05

General Comments

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