INT236525

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1f)
Cacna1f (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 43.84 Quite Low
Calcium channel 24 20.56 Low Low
Neurotransmitter 18 6.40 Low Low
Glutamate 12 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 2 65.60 Quite High
Channelopathies 34 50.00 Quite Low
Hypokalemic Periodic Paralysis 58 5.00 Very Low Very Low Very Low
Night Blindness 34 5.00 Very Low Very Low Very Low
Targeted Disruption 28 5.00 Very Low Very Low Very Low
Disease 28 5.00 Very Low Very Low Very Low
Dystonia 20 5.00 Very Low Very Low Very Low
Malignant Hyperthermia 16 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further FRET data were recently reported by the Biel group [27], which support the hypothesis that motifs further downstream of the EF hand are important for the intramolecular interaction in the Cav1.4 ?
Cav1.4 Binding (interaction) of
1) Confidence 0.39 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.07 Pain Relevance 0
N-terminus from Cav1.4wt and not Cav1.4nob2 can interact with filamin proteins
Cav1.4wt Binding (interact) of
2) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
To test whether Cav1.4wt and Cav1.4nob2 constructs differentially interact with cellular proteins, we utilized a biochemical pull-down assay.
Cav1.4nob2 Binding (interact) of
3) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
N-terminus from Cav1.4wt and not Cav1.4nob2 can interact with filamin proteins
Cav1.4nob2 Binding (interact) of
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
To test whether Cav1.4wt and Cav1.4nob2 constructs differentially interact with cellular proteins, we utilized a biochemical pull-down assay.
Cav1.4wt Binding (interact) of
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
In addition, Singh et al. imply a role of the post-IQ motif for voltage-dependent inactivation [67]. b As shown in FRET experiments [70], the Cav1.4 CTM interferes with CaM binding to one or more sites responsible for CaM pre-association (apo-CaM) in intact cells.
Cav1.4 Binding (binding) of
6) Confidence 0.29 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0 Pain Relevance 0

General Comments

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