INT23654

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 27
Total Number 38
Disease Relevance 30.85
Pain Relevance 11.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
Anatomy Link Frequency
lymph node 1
liver 1
juvenile 1
SPINK1 (Homo sapiens)
SPINK1 - N34S (8)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 837 100.00 Very High Very High Very High
fibrosis 112 100.00 Very High Very High Very High
Enkephalin 2 99.38 Very High Very High Very High
antagonist 1 95.92 Very High Very High Very High
alcohol 51 92.84 High High
Inflammation 76 87.48 High High
Pain management 15 78.24 Quite High
Bile 30 77.56 Quite High
abdominal pain 13 72.68 Quite High
Pain 31 28.08 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 1225 100.00 Very High Very High Very High
Cystic Fibrosis 74 100.00 Very High Very High Very High
Pancreatic Cancer 108 99.88 Very High Very High Very High
Cancer 307 99.76 Very High Very High Very High
Calcification 37 99.56 Very High Very High Very High
Metastasis 90 99.12 Very High Very High Very High
Diabetes Mellitus 176 98.92 Very High Very High Very High
Colon Cancer 340 98.90 Very High Very High Very High
Disease 401 96.48 Very High Very High Very High
Rectal Cancer 90 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case, the etiology-based classification system is biased toward an association with SPINK1.
SPINK1 Binding (association) of
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.98 Pain Relevance 0.63
Further investigations showed an association of SPINK1 mutations and alcoholic chronic pancreatitis as well as tropical chronic pancreatitis [36-41].
SPINK1 Binding (association) of associated with chronic pancreatitis
2) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.90 Pain Relevance 0.72
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.
SPINK1 Binding (association) of associated with calcification and pancreatitis
3) Confidence 0.39 Published 2009 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 19404200 Disease Relevance 0.68 Pain Relevance 0.18
Six of nine studies failed to identify a statistically significant association between the SPINK1 N34S polymorphism and alcoholic CP.
SPINK1 (N34S) Binding (association) of associated with chronic pancreatitis
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.69 Pain Relevance 0.46
Fourteen studies were included in this analysis (963 patients, 3,015 controls), only two of which did not detect a statistically significant association with SPINK1 N34S (figure 6).
SPINK1 (N34S) Neg (not) Binding (association) of
5) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.55 Pain Relevance 0.13
However, our observation of an individual with a combination of heterozygous SPINK1 (N34S) and CASR gene (L173P) mutations, who developed chronic pancreatitis, may indicate the specific pathogenetic background of CP within this family.
SPINK1 (N34S) Binding (combination) of associated with chronic pancreatitis
6) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.33 Pain Relevance 0.49
We have previously shown that high expression of TATI in tumour tissue correlates with an adverse prognosis in two independent cohorts of CRC patients, including the cohort studied here, in which t-TATI was also significantly associated with a reduced time to metachronous liver metastasis [3].
t-TATI Binding (associated) of in liver associated with cancer, colon cancer and metastasis
7) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.72 Pain Relevance 0
Recently, the N34S alteration of the pancreatic secretory trypsin inhibitor (PSTI) gene has been suggested to be closely associated with the pathogenesis of hereditary and/or idiopathic CP.
pancreatic secretory trypsin inhibitor Binding (associated) of associated with chronic pancreatitis
8) Confidence 0.37 Published 2001 Journal J. Hum. Genet. Section Abstract Doc Link 11355022 Disease Relevance 0.97 Pain Relevance 0.79
Recently, the N34S alteration of the pancreatic secretory trypsin inhibitor (PSTI) gene has been suggested to be closely associated with the pathogenesis of hereditary and/or idiopathic CP.
PSTI Binding (associated) of associated with chronic pancreatitis
9) Confidence 0.37 Published 2001 Journal J. Hum. Genet. Section Abstract Doc Link 11355022 Disease Relevance 0.96 Pain Relevance 0.78
Herein we analyzed genetic alterations of the PSTI gene in 32 unrelated Japanese CP patients who developed juvenile-onset CP or had a family history of CP; 5 patients were found to harbor alterations in this gene.
PSTI gene Spec (analyzed) Binding (alterations) of in juvenile associated with chronic pancreatitis
10) Confidence 0.37 Published 2001 Journal J. Hum. Genet. Section Abstract Doc Link 11355022 Disease Relevance 0.96 Pain Relevance 0.80
BACKGROUND AND AIMS: The N34S mutation in the serine protease inhibitor Kazal type I (SPINK1) gene has been associated with chronic pancreatitis.
SPINK1 Binding (associated) of associated with chronic pancreatitis
11) Confidence 0.36 Published 2009 Journal Journal of gastrointestinal and liver diseases : JGLD Section Abstract Doc Link 19565042 Disease Relevance 0.17 Pain Relevance 0.36
Research has focussed on the SPINK1-N34S-mutation, which is closely associated with tropical, alcoholic, or "idiopathic" chronic pancreatitis.
SPINK1 (N34S) Binding (associated) of associated with chronic pancreatitis
12) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15567996 Disease Relevance 1.41 Pain Relevance 0.79
While Met-enkephalin adopts a folded conformation, PSTI appears to become highly flexible, suggestive of a non-specific interaction with the micelles.
PSTI Binding (interaction) of associated with enkephalin
13) Confidence 0.36 Published 1986 Journal J. Biochem. Biophys. Methods Section Abstract Doc Link 2426327 Disease Relevance 0 Pain Relevance 0.19
Today their role is further substantiated as independent groups showed a strong association of SPINK1 mutations (N34S) in patients with tropical pancreatitis [28-30].


SPINK1 Binding (association) of associated with pancreatitis
14) Confidence 0.36 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.14 Pain Relevance 0.72
Our data also suggests that co-existence of TCF7L2 variants and the SPINK1 and CTSB mutations, that predict susceptibility to exocrine damage, may interact to determine the onset of diabetes in TCP patients.



SPINK1 Binding (interact) of associated with diabetes mellitus and pancreatitis
15) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.71 Pain Relevance 0
Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.
SPINK1 Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
16) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.78 Pain Relevance 1.06
Witt and colleagues described at first an association between mutations of the serine protease inhibitor, Kazal type 1 (SPINK1) and chronic pancreatitis [14].
Kazal type 1 Binding (association) of associated with chronic pancreatitis
17) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.28 Pain Relevance 0.59
Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.
Kazal type 1 Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
18) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.78 Pain Relevance 1.06
Witt and colleagues described at first an association between mutations of the serine protease inhibitor, Kazal type 1 (SPINK1) and chronic pancreatitis [14].
SPINK1 Binding (association) of associated with chronic pancreatitis
19) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.28 Pain Relevance 0.59
The lack of any association between s-TATI levels and t-TATI is therefore somewhat surprising, given the significant relationship between s-TATI and an adverse prognosis demonstrated in this study.
t-TATI Binding (association) of
20) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.76 Pain Relevance 0

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