INT236560

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.67
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
livers 2
adipose tissue 2
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 56 96.84 Very High Very High Very High
agonist 13 44.44 Quite Low
Eae 2 25.24 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 50 99.84 Very High Very High Very High
Diabetes Mellitus 58 99.24 Very High Very High Very High
Impaired Glucose Tolerance 46 96.84 Very High Very High Very High
Body Weight 20 83.84 Quite High
Weight Gain 6 74.56 Quite High
Targeted Disruption 21 73.16 Quite High
Stress 6 50.00 Quite Low
Dyslipidemia /

Combined Dyslipidemia

2 50.00 Quite Low
Insulin Resistance 74 43.52 Quite Low
Hyperglycemia 8 30.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data presented in this manuscript, together with our previous study in streptozotocin-induced diabetic animals (12), demonstrate that a 50% reduction of PEPCK expression results in reduced HGO and glycemia.
Negative_regulation (reduction) of Gene_expression (expression) of PEPCK associated with diabetes mellitus
1) Confidence 0.54 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.30 Pain Relevance 0
Treatment with Ad-shPck1 achieved a 42 and 25% reduction in Pck1 gene expression in fed and fasted livers, respectively (Fig. 1A).
Negative_regulation (reduction) of Gene_expression (expression) of Pck1 in livers
2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.13 Pain Relevance 0
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Negative_regulation (reduces) of Gene_expression (expression) of PEPCK
3) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.46 Pain Relevance 0.08
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Negative_regulation (downregulation) of Gene_expression (expression) of PEPCK
4) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.45 Pain Relevance 0.08
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Negative_regulation (decreased) of Gene_expression (genes) of PEPCK in adipose tissue associated with obesity
5) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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