INT236564

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 18 69.60 Quite High
agonist 29 64.16 Quite High
Inflammation 32 62.52 Quite High
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 26 84.64 Quite High
Insulin Resistance 10 84.24 Quite High
Obesity 50 74.16 Quite High
Impaired Glucose Tolerance 18 69.60 Quite High
INFLAMMATION 38 62.52 Quite High
Cancer 4 58.28 Quite High
Reprotox - General 3 2 57.80 Quite High
Aging 2 56.92 Quite High
Pathologic Processes 2 55.12 Quite High
Fibrodysplasia Ossificans Progressiva 38 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ligands induce its heterodimerization with retinoid x receptor alpha (RXR?)
Positive_regulation (induce) of retinoid x receptor alpha Binding (heterodimerization) of
1) Confidence 0.18 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.49 Pain Relevance 0.07
Interaction with the ligand induces heterodimerization with RXR and DNA binding.
Positive_regulation (induces) of RXR Binding (heterodimerization) of
2) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.40 Pain Relevance 0.09
Interaction with the ligand induces heterodimerization with RXR and DNA binding.
Positive_regulation (induces) of RXR Binding (binding) of
3) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.40 Pain Relevance 0.09

General Comments

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