INT236569

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 48 66.88 Quite High
agonist 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 62 99.44 Very High Very High Very High
Hyperglycemia 6 97.80 Very High Very High Very High
Diabetes Mellitus 38 88.80 High High
Targeted Disruption 11 84.40 Quite High
Obesity 42 84.36 Quite High
Hypoglycemia 1 69.28 Quite High
Impaired Glucose Tolerance 42 66.88 Quite High
Body Weight 20 60.64 Quite High
Stress 6 50.00 Quite Low
Dyslipidemia /

Combined Dyslipidemia

1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A twofold overexpression of PEPCK-C results in insulin resistance (4), whereas a sevenfold overexpression results in hyperglycemia (5).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PEPCK associated with hyperglycemia and insulin resistance
1) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.87 Pain Relevance 0
Overexpression of SOD1 significantly reduced the expression levels of PEPCK, the rate-limiting enzyme of gluconeogenesis.
Positive_regulation (Overexpression) of Gene_expression (expression) of PEPCK
2) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.27 Pain Relevance 0.03
The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).
Positive_regulation (depends) of Gene_expression (expression) of PEPCK
3) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.58 Pain Relevance 0
The expression level of PEPCK and Lpl was significantly increased in both wt and ?
Positive_regulation (increased) of Gene_expression (expression) of PEPCK
4) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0

General Comments

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