INT236569

Context Info Confidence 0.64 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.88 Pain Relevance 0.03

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1) lipid metabolic process (Pck1) cytoplasm (Pck1)

Pck1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 48 66.88 agonist 12 5.00 anesthesia 6 5.00 cytokine 4 5.00 isoflurane 3 5.00 Eae 2 5.00 imagery 2 5.00 dexamethasone 1 5.00 Kinase C 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 62 99.44 Hyperglycemia 6 97.80 Diabetes Mellitus 38 88.80 Targeted Disruption 11 84.40 Obesity 42 84.36 Hypoglycemia 1 69.28 Impaired Glucose Tolerance 42 66.88 Body Weight 20 60.64 Stress 6 50.00 Dyslipidemia / Combined Dyslipidemia 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A twofold overexpression of PEPCK-C results in insulin resistance (4), whereas a sevenfold overexpression results in hyperglycemia (5).

Positive_regulation (overexpression) of Gene_expression (overexpression) of PEPCK associated with hyperglycemia and insulin resistance

1) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.87 Pain Relevance 0

Overexpression of SOD1 significantly reduced the expression levels of PEPCK, the rate-limiting enzyme of gluconeogenesis.

Positive_regulation (Overexpression) of Gene_expression (expression) of PEPCK

2) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.27 Pain Relevance 0.03

The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).

Positive_regulation (depends) of Gene_expression (expression) of PEPCK

3) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.58 Pain Relevance 0

The expression level of PEPCK and Lpl was significantly increased in both wt and ?

Positive_regulation (increased) of Gene_expression (expression) of PEPCK

4) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0

General Comments

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