INT236571

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.17
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ncoa1) nucleus (Ncoa1) transferase activity, transferring acyl groups (Ncoa1)
DNA binding (Ncoa1) signal transducer activity (Ncoa1)
Anatomy Link Frequency
brain 3
intermediary 1
Ncoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 24 98.96 Very High Very High Very High
dexamethasone 28 92.00 High High
tolerance 18 48.08 Quite Low
agonist 11 30.72 Quite Low
cytokine 39 5.00 Very Low Very Low Very Low
Kinase C 36 5.00 Very Low Very Low Very Low
Neuropeptide 27 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 15 71.20 Quite High
Diabetes Mellitus 6 51.20 Quite High
Insulin Resistance 8 50.80 Quite High
Impaired Glucose Tolerance 18 48.72 Quite Low
Obesity 30 40.72 Quite Low
Weight Loss 4 16.08 Low Low
Stress 84 5.00 Very Low Very Low Very Low
Targeted Disruption 31 5.00 Very Low Very Low Very Low
Hyponatremia 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of nuclear coactivators such as steroid receptor coactivator 1 (SRC1) and transcriptional intermediary factor 2 (TIF2) prevented the ER?
Transcription (transcriptional) of SRC1 in intermediary
1) Confidence 0.50 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.17 Pain Relevance 0
The SRC family members are highly expressed in the brain and have a distinct expression pattern: SRC-1a mRNA is strongly expressed in the magnocellular and parvocellular parts of PVN and SON, whereas the expression level of SRC-1e mRNA is very high in the amygdala and much lower in PVN (Maijer et al. 2000).
Transcription (expressed) of SRC-1a in brain associated with amygdala
2) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.23
The SRC family members are highly expressed in the brain and have a distinct expression pattern: SRC-1a mRNA is strongly expressed in the magnocellular and parvocellular parts of PVN and SON, whereas the expression level of SRC-1e mRNA is very high in the amygdala and much lower in PVN (Maijer et al. 2000).
Transcription (level) of SRC-1e in brain associated with amygdala
3) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.20
The SRC family members are highly expressed in the brain and have a distinct expression pattern: SRC-1a mRNA is strongly expressed in the magnocellular and parvocellular parts of PVN and SON, whereas the expression level of SRC-1e mRNA is very high in the amygdala and much lower in PVN (Maijer et al. 2000).
Transcription (expression) of SRC-1e in brain associated with amygdala
4) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.20

General Comments

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