INT236576

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.39
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 90 98.40 Very High Very High Very High
ischemia 67 93.92 High High
Central nervous system 56 91.20 High High
Hippocampus 16 80.28 Quite High
tolerance 18 78.40 Quite High
cytokine 46 63.80 Quite High
agonist 13 60.96 Quite High
cerebral cortex 1 32.56 Quite Low
Demyelination 10 30.60 Quite Low
Multiple sclerosis 242 21.52 Low Low
Disease Link Frequency Relevance Heat
Stroke 14 99.68 Very High Very High Very High
Targeted Disruption 18 98.76 Very High Very High Very High
INFLAMMATION 94 98.40 Very High Very High Very High
Multiple Sclerosis 442 94.56 High High
Brain Hemorrhage 2 93.92 High High
Repression 1 93.44 High High
Impaired Glucose Tolerance 18 79.04 Quite High
Cv General 4 Under Development 59 75.12 Quite High
Disease 206 72.88 Quite High
Toxicity 2 62.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue specific differences in biologic outcomes are thought to be due, in part, to tissue specific differences in transcription factors which become activated upon binding of each oestrogen receptor (ER) by ligand [191-193].
Positive_regulation (activated) of ER Binding (binding) of
1) Confidence 0.41 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.40 Pain Relevance 0.05
Since treatment with an ER?
Positive_regulation (Since) of ER Binding (treatment) of
2) Confidence 0.36 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.23 Pain Relevance 0.56
is a result of p160 coactivator interaction with ER?
Positive_regulation (coactivator) of ER Binding (interaction) of
3) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.17 Pain Relevance 0.04
knockout mice had a dramatic loss of E2 neuroprotection [13], further supporting a critical role for ER?
Positive_regulation (supporting) of ER Binding (role) of associated with targeted disruption
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.59 Pain Relevance 0.28

General Comments

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