INT236578

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.25
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
face 4
macrophage 2
adipose tissue 2
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 3 71.44 Quite High
cytokine 13 64.40 Quite High
tolerance 18 59.20 Quite High
agonist 59 47.48 Quite Low
Inflammation 6 29.48 Quite Low
Eae 2 25.24 Quite Low
Inflammatory response 3 21.40 Low Low
Kinase C 1 8.08 Low Low
Potency 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 318 99.84 Very High Very High Very High
Diabetes Mellitus 34 98.44 Very High Very High Very High
Atherosclerosis 11 98.04 Very High Very High Very High
Disorder Of Lipid Metabolism 2 90.56 High High
Retinoblastoma 2 84.60 Quite High
Body Weight 16 83.84 Quite High
Hypertension 2 81.04 Quite High
Coronary Artery Disease 1 79.92 Quite High
Myocardial Infarction 2 76.16 Quite High
Cv General 4 Under Development 1 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated suppression of LPL mRNA expression, protein levels and enzymatic activity has been observed in a range of macrophage sources from different species, including human monocyte-derived macrophages [7–9].
Negative_regulation (suppression) of Gene_expression (expression) of LPL mRNA in macrophage
1) Confidence 0.25 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.47 Pain Relevance 0.03
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Negative_regulation (decreased) of Gene_expression (genes) of Lpl in adipose tissue associated with obesity
2) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.34 Pain Relevance 0.03
Nevertheless, expression of LPL remains robust in fully developed adipocytes [2, 18, 19], indicating that other factors sustain LPL expression in the face of reduced PPAR?
Negative_regulation (robust) of Gene_expression (expression) of LPL in face associated with obesity
3) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.44 Pain Relevance 0
Nevertheless, expression of LPL remains robust in fully developed adipocytes [2, 18, 19], indicating that other factors sustain LPL expression in the face of reduced PPAR?
Negative_regulation (sustain) of Gene_expression (expression) of LPL in face associated with obesity
4) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.45 Pain Relevance 0
Resveratrol also represses the expression of the lipid uptake genes lipoprotein lipase and scavenger receptor AII (SR-AII) (Sevov et al 2006).
Negative_regulation (represses) of Gene_expression (expression) of lipoprotein lipase
5) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.56 Pain Relevance 0.06

General Comments

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