INT2366

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Context Info
Confidence 0.48
First Reported 1977
Last Reported 2009
Negated 7
Speculated 11
Reported most in Abstract
Documents 192
Total Number 203
Disease Relevance 30.64
Pain Relevance 163.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
brain 11
central nervous system 7
spinal cord 6
cerebral cortex 6
nucleus accumbens 5
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 1382 100.00 Very High Very High Very High
Morphine 354 100.00 Very High Very High Very High
antagonist 272 100.00 Very High Very High Very High
opiate 227 100.00 Very High Very High Very High
Pain 219 100.00 Very High Very High Very High
Opioid 198 100.00 Very High Very High Very High
Enkephalin 115 100.00 Very High Very High Very High
Analgesic 85 100.00 Very High Very High Very High
Neurotransmitter 78 100.00 Very High Very High Very High
Neuropeptide 75 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 1 99.84 Very High Very High Very High
Hypotension 2 99.80 Very High Very High Very High
Pain 180 99.76 Very High Very High Very High
Urological Neuroanatomy 70 99.76 Very High Very High Very High
Opiate Addiction 16 99.76 Very High Very High Very High
Panic Disorder 60 99.52 Very High Very High Very High
Natriuresis 1 99.46 Very High Very High Very High
Hyperalgesia 2 99.32 Very High Very High Very High
Obesity 15 99.30 Very High Very High Very High
INFLAMMATION 38 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study used behavioral measures to determine how CCK interacts with opiates in neonatal rats.
CCK Binding (interacts) of associated with opiate and cholecystokinin
1) Confidence 0.48 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3202224 Disease Relevance 0.11 Pain Relevance 1.25
In adult mammals, cholecystokinin (CCK)-opiate interactions are complex and task dependent.
CCK Binding (interactions) of associated with opiate and cholecystokinin
2) Confidence 0.48 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3202224 Disease Relevance 0 Pain Relevance 1.03
In adult mammals, cholecystokinin (CCK)-opiate interactions are complex and task dependent.
cholecystokinin Binding (interactions) of associated with opiate and cholecystokinin
3) Confidence 0.48 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3202224 Disease Relevance 0 Pain Relevance 1.03
These findings suggest independence of stress and pain systems in neonatal rats and demonstrate a functional interaction between CCK and opioid systems.
CCK Binding (interaction) of associated with stress, pain, opioid and cholecystokinin
4) Confidence 0.48 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3202224 Disease Relevance 0.20 Pain Relevance 1.34
Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats.
cholecystokinin Binding (interactions) of associated with pain, opiate and cholecystokinin
5) Confidence 0.48 Published 1988 Journal Am. J. Physiol. Section Title Doc Link 3202224 Disease Relevance 0.13 Pain Relevance 1.48
We have utilized the well-characterized hippocampal response to opioids to examine the potential interactions between morphine and the neuropeptide cholecystokinin (CCK) in vitro.
neuropeptide cholecystokinin Binding (interactions) of associated with neuropeptide, cholecystokinin, opioid and morphine
6) Confidence 0.48 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113987 Disease Relevance 0 Pain Relevance 1.32
We have utilized the well-characterized hippocampal response to opioids to examine the potential interactions between morphine and the neuropeptide cholecystokinin (CCK) in vitro.
CCK Binding (interactions) of associated with neuropeptide, cholecystokinin, opioid and morphine
7) Confidence 0.48 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113987 Disease Relevance 0 Pain Relevance 1.32
Differential interaction of cholecystokinin with morphine and phencyclidine: effects on operant behavior in pigeons.
cholecystokinin Binding (interaction) of associated with cholecystokinin and morphine
8) Confidence 0.48 Published 1992 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 1539083 Disease Relevance 0 Pain Relevance 0.68
Our studies provide further evidence for a 5-HT/CCK interaction in the regulation of anxiety.
CCK Binding (interaction) of associated with anxiety disorder and cholecystokinin
9) Confidence 0.48 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10218869 Disease Relevance 0.10 Pain Relevance 0.72
The present study suggests that the modulatory interaction between CCK and opioids in the development of tolerance in the spinal cord may occur without necessarily increasing the extracellular level of CCK.
CCK Binding (interaction) of in spinal cord associated with tolerance, opioid and spinal cord
10) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.24
Behavioral evidence for the involvement of endogenous opioids in the interaction between cholecystokinin and brain dopamine systems.
cholecystokinin Binding (interaction) of in brain associated with dopamine, narcan, endogenous opioid and cholecystokinin
11) Confidence 0.48 Published 1987 Journal Neurosci. Lett. Section Title Doc Link 3561887 Disease Relevance 0.10 Pain Relevance 0.78
The aim of this study was to investigate the possible interaction between neuronal cholecystokinin (CCK) and opiate dependence.
CCK Binding (interaction) of in neuronal associated with addiction, opiate and cholecystokinin
12) Confidence 0.48 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8090802 Disease Relevance 0.17 Pain Relevance 1.04
Intrathecal cholecystokinin interacts with morphine but not substance P in modulating the nociceptive flexion reflex in the rat.
cholecystokinin Binding (interacts) of associated with nociception, cholecystokinin, substance p, morphine and intrathecal
13) Confidence 0.48 Published 1987 Journal Peptides Section Title Doc Link 2437547 Disease Relevance 0.45 Pain Relevance 2.05
Thus, enkephalin and CCK interact to modulate amphetamine-induced locomotor stereotypy.
CCK Binding (interact) of associated with enkephalin
14) Confidence 0.48 Published 1990 Journal Brain Res. Section Abstract Doc Link 2350675 Disease Relevance 0 Pain Relevance 0.67
These data suggest that the nucleus accumbens may be another structure where interactions between opioids and cholecystokinin play a key role in the control of pain-processing mechanisms.
cholecystokinin Binding (interactions) of in nucleus accumbens associated with pain, nucleus accumbens, cholecystokinin and opioid
15) Confidence 0.48 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11330333 Disease Relevance 0.17 Pain Relevance 0.89
The interaction between cholecystokinin and endogenous opioid systems on rewarding responses was examined.
cholecystokinin Binding (interaction) of associated with endogenous opioid and cholecystokinin
16) Confidence 0.48 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8741934 Disease Relevance 0 Pain Relevance 0.45
Recent ligand binding studies have shown that CCK receptors in the spinal cord of the rat (where CCK/opiate interactions are thought to occur) are predominantly of the CCK-B subtype.
CCK Binding (interactions) of in spinal cord associated with opiate and spinal cord
17) Confidence 0.48 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2725851 Disease Relevance 0.26 Pain Relevance 1.91
Cholecystokinin/opioid interactions.
Cholecystokinin Binding (interactions) of associated with opioid and cholecystokinin
18) Confidence 0.48 Published 1999 Journal Brain Res. Section Title Doc Link 10612699 Disease Relevance 0.25 Pain Relevance 1.42
L-364,718 did not interact with opioid receptors (assay limit of solubility, 10 microM) but had a high affinity for CCK binding sites (IC50, 126nM).
CCK Binding (affinity) of associated with opioid receptor
19) Confidence 0.48 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2174522 Disease Relevance 0.07 Pain Relevance 0.68
Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L-364,718, interact with brain opioid binding sites.
Cholecystokinin Binding (interact) of in brain associated with antagonist, opioid and cholecystokinin
20) Confidence 0.48 Published 1990 Journal Neuropeptides Section Title Doc Link 2174522 Disease Relevance 0.09 Pain Relevance 0.74

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